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Drug Management in the Elderly Adult With Chronic Kidney Disease: A Review for the Primary Care Physician
Mayo Clinic ProceedingsVol. 90Issue 5p633–645Published online: March 12, 2015- Claudio Ponticelli
- Gabriele Sala
- Richard J. Glassock
Cited in Scopus: 30With advancing age, the functional reserve of many organs tends to decrease. In particular, the lean body mass, the levels of serum albumin, the blood flow to the liver, and the glomerular filtration rate are reduced in elderly individuals and can be further impaired by the concomitant presence of acute or chronic kidney disease. Moreover, patients with kidney disease are often affected by comorbid processes and are prescribed multiple medications. The aging process also modifies some drug interactions, including the affinity of some drugs for their receptor, the number of receptors, and the cell responses upon receptor activation.
