Skip to Main Content

Opioids

1 Results

SUPPLEMENT ARTICLE
Treatment Considerations for Patients With Neuropathic Pain and Other Medical Comorbidities
Mayo Clinic Proceedings
Vol. 85Issue 3SupplementS15–S25Published in issue: March, 2010
- Maija L. Haanpää
- Geoffrey K. Gourlay
- Joel L. Kent
- Christine Miaskowski
- Srinivasa N. Raja
- Kenneth E. Schmader
- and others
Cited in Scopus: 72
The efficacy of drugs for neuropathic pain has been established in randomized controlled trials that have excluded patients with comorbid conditions and those taking complex medications. However, patients with neuropathic pain frequently present with complex histories, making direct application of this evidence problematic. Treatment of neuropathic pain needs to be individualized according to the cause of the pain, concomitant diseases, medications, and other individual factors. Tricyclic antidepressants (TCAs), gabapentinoids, selective noradrenergic reuptake inhibitors, and topical lidocaine are the first-line choices; if needed, combination therapy may be used.