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The Sickle Cell Crisis: A Dilemma in Pain Relief
Mayo Clinic ProceedingsVol. 83Issue 3p320–323Published in issue: March, 2008- Alan K. Geller
- M. Kevin O'Connor
Cited in Scopus: 29Sickle cell anemia is a progressive hemoglobinopathy producing chronic hemolytic anemia, microvascular thrombosis, ischemic pain, tissue infarction, decreased quality of life, and ultimately shortened life expectancy.1,2 In sickle cell anemia, valine is substituted for glutamic acid in the sixth amino acid of the β-globin chain. In a person who is homozygous, all hemoglobin is of the abnormal HbS type, and repeated episodes of sickling result in a less malleable molecule even at sites of normal atmospheric pressures of oxygen.
