The Sickle Cell Crisis: A Dilemma in Pain ReliefSickle cell anemia is a progressive hemoglobinopathy producing chronic hemolytic anemia, microvascular thrombosis, ischemic pain, tissue infarction, decreased quality of life, and ultimately shortened life expectancy.1,2 In sickle cell anemia, valine is substituted for glutamic acid in the sixth amino acid of the β-globin chain. In a person who is homozygous, all hemoglobin is of the abnormal HbS type, and repeated episodes of sickling result in a less malleable molecule even at sites of normal atmospheric pressures of oxygen.
Current Pain ManagementType and Scope of Book: A multiauthored compilation of topics that are relevant to contemporary management of cancer pain, with a multidisciplinary approach to appeal to a broad readership.
The Role of Drug Treatments for Eating DisordersIn this concise multiauthored book, the theory and practice of drug treatments for patients with anorexia nervosa and bulimia nervosa are reviewed. The following substances are discussed: monoamine oxidase inhibitors, tricyclic antidepressants, antianxiety drugs, neuroleptics, lithium, anticonvulsants, drugs that affect serotonin, opioid antagonists, and drugs that facilitate gastric emptying. In this evolving area of practice, whether to use medications in the treatment of patients with eating disorders is a hotly debated issue.