Letters to the Editor
- The meta-analysis and review by Banach et al1 published in the January 2015 issue of Mayo Clinic Proceedings presented interesting but disappointing results for those who hoped that coenzyme Q10 (CoQ10) would prove to be the antidote for the muscle pains and myopathy induced by statin use in susceptible patients.
- The meta-analysis by Huang et al1 in the September 2014 issue of Mayo Clinic Proceedings revealed an association between low to moderate ethanol consumption and reduced risk of cardiovascular disease and all-cause mortality (ACM) in hypertensive patients. This study adds additional observational evidence to support the hypothesis that there is a J-shaped curve for ACM vs ethanol consumption, with minimum ACM observed in persons with a low-level long-term ethanol intake of about 10 g/d (about 1 standard serving or drink).
- Pittman et al1 recently reported that bisphosphonate use was associated with an increased risk of incident acute myocardial infarction (AMI) in their observational study of elderly veterans with a history of osteoporotic fractures. Of note, they also reported that “the timing of AMI correlated closely with the timing of bisphosphonate therapy initiation.”
- As a community-based primary care physician, I found the recent review of safety concerns regarding citalopram by Sheeler et al1 very helpful. I would like to offer the following further comments and questions.