Introduction to the Symposium on NeurosciencesIn the current issue of Mayo Clinic Proceedings, the Journal will publish the first of many articles that will appear in sequential issues as part of the Symposium on Neurosciences. The Symposium represents an ambitious attempt to survey the immense and rapidly growing field of neuroscience and glean from it information that will be of interest to, and provide utility for, a general medical readership. The articles will be authored by leading experts in their fields who seek to provide a balanced representation of contemporary and evolving knowledge about neurologic diseases and the scientific foundations that underlie them.
New Insights Into the Mechanisms Underlying Efficacious Deep Brain StimulationIn this issue of Mayo Clinic Proceedings, Chang and an international team of collaborators—collectively representing departments of neurosurgery, physiology and biomedical engineering, and engineering at Mayo Clinic in Rochester, Minnesota; Hanyang University in Seoul, South Korea; Soonchunhyang University in Bucheon, South Korea; Illinois State University in Normal, Illinois; and the University of Memphis in Memphis, Tennessee—present a fascinating and important novel discovery that offers insights into how deep brain stimulation (DBS) may work at the cellular level.
New Uses for Older Drugs: The Tales of Aspirin, Thalidomide, and GabapentinIn this issue of Mayo Clinic Proceedings, 2 articles describe original research in which gabapentin therapy produced novel, beneficial effects in patients with chronic neurologic conditions. Bogan et al1 report that gabapentin enacarbil, a gabapentin prodrug, may be useful for maintenance treatment of restless legs syndrome. Pistoia et al2 document a case series that suggests efficacy of gabapentin for treating opsoclonus-myoclonus syndrome in paralyzed patients with locked-in syndrome. The benefit from gabapentin treatment included opening a window of communication with the otherwise noncommunicative patients.