A 36-year-old male patient newly diagnosed as having human immunodeficiency virus/acquired immunodeficiency syndrome with a CD4 count on presentation of 3 cells/μL presented with an oral lesion. This lesion was previously thought to be a dental abscess that persisted despite incision and drainage (Figure). The lesion had a raised nodular appearance, was purple, and seemed to be of vascular origin. This was highly suspicious for Kaposi sarcoma. This suspicion was confirmed by a biopsy showing tumor cells positive for CD31 and human herpesvirus 8.