Patients and Methods
ABBREVIATIONS:ARDS (acute respiratory distress syndrome), ARF (acute respiratory failure), AST (aspartate aminotransferase), AUC (area under the curve), c-LIPS (lung injury prediction score for COVID-19 patients), COVID-19 (Coronavirus disease 2019), CRP (C-reactive protein), HFNC (high flow nasal cannula), IQR (interquartile range), LIPS (lung injury prediction score), PaO2/FiO2 (partial pressure of arterial oxygen to fractional inspired oxygen ratio), ROC (receiver operating characteristic), SCCM (Society of Critical Care Medicine), SpO2 (oxygen saturation), VIRUS (Viral Infection and Respiratory Illness Universal Study), WHO (World Health Organization)
Publication stageIn Press Accepted Manuscript
Financial support and conflict of interest disclosure:
This publication was supported by NIH/NCRR/NCATS CTSA Grant Number UL1 TR002377. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. The VIRUS registry is funded in part by the Gordon and Betty Moore Foundation, and Janssen Research & Development, LLC. They had no influence on analysis, interpretation and reporting of pooled data. This study was supported by the Mayo Clinic Critical Care Independent Multidisciplinary Program (IMP) Research Subcommittee. They had no influence on the analysis, interpretation, and reporting of pooled data.
R.K. receives funding from the National Institutes of Health/National Heart, Lung and Blood Institute: R01HL 130881, UG3/UH3HL 141722; Gordon and Betty Moore Foundation, and Janssen Research & Development, LLC; and royalties from Ambient Clinical Analytics. Inc. They had no influence on the acquisition, analysis, interpretation, and reporting of pooled data for this manuscript.
AJW receives funding from the National Institutes of Health/National Heart, Lung and Blood Institute grants R01HL151607, R01HL139751, R01HL136660, Agency of Healthcare Research and Quality, R01HS026485, Boston Biomedical Innovation Center/NIH/NHLBI 5U54HL119145-07 and royalties from UpToDate.
HY receives funding from the National Heart, Lung, and Blood Institute: K23HL151671.
OG receives funding from the Agency of Healthcare Research and Quality R18HS 26609-2, National Institutes of Health/National Heart, Lung and Blood Institute: R01HL 130881, UG3/UH3HL 141722; Department of Defense DOD W81XWH; American Heart Association Rapid Response Grant – COVID-19; and royalties from Ambient Clinical Analytics. Inc.
Clinical Trial Registration: Clinical Trials Database registration number for the VIRUS registry is NCT04323787.