Abstract
Objective
To study differences in cardiovascular risk factors and diseases between patients
with and without genetic variants in the leptin-melanocortin pathway.
Methods
A cross-sectional study of patients with a history of severe obesity genotyped in
June 2019 as participants of the Mayo Clinic Biobank was conducted in March 2022 to
assess differences in cardiovascular risk and diseases between carriers of a heterozygous
variant in the leptin-melanocortin pathway and noncarriers. Cardiovascular risk factors
included hypertension, diabetes, dyslipidemia, and smoking. Cardiovascular disease
includes coronary artery disease, peripheral artery disease, and cerebrovascular accidents.
Patients with a history of bariatric surgery were excluded. We used logistic regression
models to estimate the odds ratio and 95% CI, adjusting for age, body mass index (BMI),
and sex.
Results
Among a total of 168 carriers (8%; 121 [72%] female; mean [SD] age, 65.1 [14.9] years;
BMI, 44.0 [7.4] kg/m2) and 2039 noncarriers (92%; 1446 [71%] female; mean [SD] age, 64.9 [14.4] years;
BMI, 42.9 [6.6] kg/m2), carriers had higher prevalence odds of hypertension (odds ratio, 3.26; 95% CI,
2.31 to 4.61; P<.001) and reported higher number of cardiovascular risk factors compared with noncarriers
(2.4 [1.1] vs 2.0 [1.1]; P<.001). There were no significant differences in the adjusted odds associated with
diabetes, dyslipidemia, smoking, or cardiovascular disease.
Conclusion
Despite having similar body weight and BMI, carriers of heterozygous variants in the
leptin-melanocortin pathway had higher rates of hypertension than noncarriers. These
findings point to an association between hypertension and leptin-melanocortin pathway
variants.
Abbreviations and Acronyms:
BMI (body mass index), CVD (cardiovascular disease), MC4R (melanocortin 4 receptor), OR (odds ratio), POMC (proopiomelanocortin)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: December 20, 2022
Publication stage
In Press Corrected ProofFootnotes
Grant Support: Dr Acosta is supported by the National Institutes of Health (NIH K23-DK114460), the Mayo Clinic Biobank, and Rhythm Pharmaceuticals for the genotyping studies. The Mayo Clinic Biobank is supported by the Mayo Clinic Center for Individualized Medicine.
Data Access: Dr Acosta has full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Identification
Copyright
© 2022 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
