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Oncocytic Parathyroid Adenoma

      A woman in her 60s presented with primary hyperparathyroidism. The parathyroid gland removed weighed 300 mg and was composed almost entirely of oncocytic cells with a “rim” of normocellular/suppressed-appearing parathyroid tissue (Figures 1 and 2).
      Which of the following statements regarding oncocytic parathyroid adenoma is true?
      • a.
        Oncocytic parathyroid neoplasms are functional and associated with increased parathyroid hormone and serum calcium levels.
      • b.
        Oncocytic parathyroid neoplasms are always benign.
      • c.
        Oncocytic parathyroid neoplasms occur only in women.
      • d.
        Oncocytic cells are identified only in single-gland parathyroid disease and are not seen in multiglandular parathyroid disease.
      Answer: a. Oncocytic parathyroid neoplasms are functional and associated with increased parathyroid hormone and serum calcium levels.

      References

        • Erickson L.A.
        • Jin L.
        • Papotti M.
        • Lloyd R.V.
        Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases.
        Am J Surg Pathol. 2002; 26: 344-349
        • Erickson L.A.
        • Mete O.
        • Juhlin C.C.
        • Perren A.
        • Gill A.J.
        Overview of the 2022 WHO classification of parathyroid tumors.
        Endocr Pathol. 2022; 33: 64-89