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Anastomosing Hemangioma

      An older man presented with a periadrenal mass. The tumor was resected and showed an anastomosing hemangioma.
      What is the most accurate statement regarding this tumor?
      • a.
        Anastomosing hemangioma is the most common type of hemangioma.
      • b.
        Anastomosing hemangioma most commonly occurs in the distal extremities.
      • c.
        Anastomosing hemangiomas have been found to have recurrent GNAQ and GNA14 mutations.
      • d.
        Anastomosing hemangioma is a high-grade malignant vascular tumor.
      Answer: c. Anastomosing hemangiomas have been found to have recurrent GNAQ and GNA14 mutations.
      Anastomosing hemangioma is a benign vascular tumor that has a predilection for the retroperitoneum and genitourinary tract as well as for the paraspinal region.
      • John I.
      • Folpe A.L.
      Anastomosing hemangiomas arising in unusual locations: a clinicopathologic study of 17 soft tissue cases showing a predilection for the paraspinal region.
      ,
      • Montgomery E.
      • Epstein J.I.
      Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma.
      These tumors are often incidentally identified. The tumors have a spongy consistency and on histologic evaluation are composed of capillary vessels with an anastomosing and sinusoidal pattern. The tumors lack the markedly infiltrative growth pattern present in angiosarcoma. Anastomosing hemangiomas have been found to have recurrent GNAQ and GNA14 mutations.
      • Bean G.R.
      • Joseph N.M.
      • Gill R.M.
      • Folpe A.L.
      • Horvai A.E.
      • Umetsu S.E.
      Recurrent GNAQ mutations in anastomosing hemangiomas.
      ,
      • Bean G.R.
      • Joseph N.M.
      • Folpe A.L.
      • Horvai A.E.
      • Umetsu S.E.
      Recurrent GNA14 mutations in anastomosing haemangiomas.

      References

        • John I.
        • Folpe A.L.
        Anastomosing hemangiomas arising in unusual locations: a clinicopathologic study of 17 soft tissue cases showing a predilection for the paraspinal region.
        Am J Surg Pathol. 2016; 40: 1084-1089
        • Montgomery E.
        • Epstein J.I.
        Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma.
        Am J Surg Pathol. 2009; 33: 1364-1369
        • Bean G.R.
        • Joseph N.M.
        • Gill R.M.
        • Folpe A.L.
        • Horvai A.E.
        • Umetsu S.E.
        Recurrent GNAQ mutations in anastomosing hemangiomas.
        Mod Pathol. 2017; 30: 722-727
        • Bean G.R.
        • Joseph N.M.
        • Folpe A.L.
        • Horvai A.E.
        • Umetsu S.E.
        Recurrent GNA14 mutations in anastomosing haemangiomas.
        Histopathology. 2018; 73: 354-357