Abstract
Objective
To estimate the incidence of invasive pneumococcal disease (IPD) in the pre–13-valent
pneumococcal conjugate vaccine (pre-PCV13; 7-valent pneumococcal conjugate vaccine
era, 2002-2010) and post-PCV13 (2011-2018) time periods.
Patients and Methods
Using the Rochester Epidemiology Project, we conducted a population-based cohort study
of all IPD cases in Olmsted County, Minnesota, from January 1, 2002, to December 31, 2018.
Results
Overall, 187 cases of IPD were identified. The incidence of IPD decreased significantly
from 11.1 (95% CI, 9.1 to 13.2) to 5.6 (95% CI, 4.3 to 6.9) per 100,000 person-years
when the pre- and post-PCV13 periods (2002-2010 vs 2011-2018) were compared (P<.001). Of the 187 patients with IPD, 112 (59.9%) had previously received at least
1 dose of pneumococcal vaccine. Among the IPD cases in the post-PCV13 period, there
was an increase in non-PCV13 serotypes, mainly 11A (from 1.0% [1 of 105] to 6.2% [4
of 64]) and 33F (from 2.9% [3 of 105] to 15.6% [10 of 64]), while PCV13/non–7-valent
pneumococcal conjugate vaccine serotypes declined from 38.1% (40 of 105) to 15.6%
(10 of 64). At 30 days after an IPD diagnosis, the survival rate was 88.8% (95% CI,
84.4% to 93.4%).
Conclusion
A marked decline in IPD incidence occurred during the post-PCV13 era. Because of the
observed increase in non-PCV13 serotypes, coupled with multiple factors that impact
the epidemiology of IPD, ongoing surveillance of patients with IPD, particularly due
to non-PCV13 serotypes, is warranted.
Abbreviations and Acronyms:
ABCS (Active Bacterial Core Surveillance), CSF (cerebrospinal fluid), IPD (invasive pneumococcal disease), PCV (pneumococcal conjugate vaccine), PCV7 (7-valent pneumococcal conjugate vaccine), PCV13 (13-valent pneumococcal conjugate vaccine), PPSV23 (23-valent pneumococcal polysaccharide vaccine), REP (Rochester Epidemiology Project)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: November 05, 2022
Accepted:
June 30,
2022
Received in revised form:
May 29,
2022
Received:
January 8,
2022
Footnotes
Grant Support: This research was made possible through support from the Division of Allergic Diseases, Small Grant Project and grant UL1TR000135 to the Mayo Clinic Center for Clinical and Translational Science from the National Center for Advancing Translational Sciences.
Identification
Copyright
© 2022 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
