Abstract
Objective
Methods
Results
Conclusions
Abbreviations and Acronyms:
CHD (coronary heart disease), DIY (do-it-yourself), GRS (genetic risk score), HR (hazard ratio), MET (metabolic equivalent of task), SNP (single-nucleotide polymorphism)Purchase one-time access:
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- Sitting time and risk of cardiovascular disease and diabetes: a systematic review and meta-analysis.Am J Prev Med. 2019; 57: 408-416
- Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a meta-analysis.JAMA. 2011; 305: 2448-2455
- Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults.Ann Intern Med. 2015; 162 (Published correction appears in Ann Intern Med. 2015;163(5):400): 123-132
- Amount of time spent in sedentary behaviors in the United States, 2003-2004.Am J Epidemiol. 2008; 167: 875-881
- Trends in sedentary behavior among the US population, 2001-2016.JAMA. 2019; 321: 1587-1597
- World Health Organization 2020 guidelines on physical activity and sedentary behaviour.Br J Sports Med. 2020; 54: 1451-1462
- Physical activity guidelines for Americans from the US Department of Health and Human Services.Circ Cardiovasc Qual Outcomes. 2018; 11e005263
- Physical Activity Guidelines for Americans.2nd ed. US Department of Health and Human Services, 2018
- Isotemporal substitution paradigm for physical activity epidemiology and weight change.Am J Epidemiol. 2009; 170: 519-527
- Isotemporal substitution as the gold standard model for physical activity epidemiology: why it is the most appropriate for activity time research.Int J Environ Res Public Health. 2019; 16: 797
- UK chief medical officers’ physical activity guidelines.(September 2019. Accessed April 4, 2022)
- What makes UK Biobank special?.Lancet. 2012; 379: 1173-1174
- UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age.PLoS Med. 2015; 12e1001779
- Sedentary behavior research network (SBRN)—Terminology Consensus Project process and outcome.Int J Behav Nutr Phys Act. 2017; 14: 75
- WHO guidelines on physical activity and sedentary behaviour. 2020 (Accessed April 4, 2022)
- Replacement of sedentary behavior by various daily-life physical activities and structured exercises: genetic risk and incident type 2 diabetes.Diabetes Care. 2021; 44: 2403-2410
- Television viewing and incident cardiovascular disease: prospective associations and mediation analysis in the EPIC Norfolk Study.PLoS One. 2011; 6e20058
- Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic impact goal through 2020 and beyond.Circulation. 2010; 121: 586-613
Bycroft C, Freeman C, Petkova D, et al. Genome-wide genetic data on ∼500,000 UK Biobank participants. Preprint. Posted online July 20, 2017. bioRxiv. doi:10.1101/166298
- The UK Biobank resource with deep phenotyping and genomic data.Nature. 2018; 562: 203-209
- A comprehensive 1,000 Genomes–based genome-wide association meta-analysis of coronary artery disease.Nat Genet. 2015; 47: 1121-1130
- Sugar-sweetened beverages and genetic risk of obesity.N Engl J Med. 2012; 367: 1387-1396
- Isotemporal substitution analysis for physical activity, television watching, and risk of depression.Am J Epidemiol. 2013; 178: 474-483
- Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis.Ann Intern Med. 2015; 162 (Published correction appears in Ann Intern Med. 2015;163(5):400): 123-132
- Continuous dose-response association between sedentary time and risk for cardiovascular disease: a meta-analysis.JAMA Cardiol. 2016; 1: 575-583
- Relationship of sedentary behavior and physical activity to incident cardiovascular disease: results from the Women’s Health Initiative.J Am Coll Cardiol. 2013; 61: 2346-2354
- Reallocating time to sleep, sedentary behaviors, or active behaviors: associations with cardiovascular disease risk biomarkers, NHANES 2005-2006.Am J Epidemiol. 2014; 179: 323-334
- Physical activity and abdominal fat distribution in Greenland.Med Sci Sport Exerc. 2017; 49: 2064-2070
- Sedentary behavior, physical activity, and fitness—The Maastricht Study.Med Sci Sports Exerc. 2017; 49: 1583-1591
- SCAPIS pilot study: sitness, fitness and fatness—is sedentary time substitution by physical activity equally important for everyone’s markers of glucose regulation?.J Phys Act Health. 2016; 13: 697-703
- Health outcomes associated with reallocations of time between sleep, sedentary behaviour, and physical activity: a systematic scoping review of isotemporal substitution studies.Int J Behav Nutr Phys Act. 2018; 15: 69
- Health outcomes associated with reallocations of time between sleep, sedentary behaviour, and physical activity.Public Health. 2019; 167: 96-102
- Physical activity, sitting, and risk factors of cardiovascular disease: a cross-sectional analysis of the CARRS study.J Behav Med. 2019; 42: 502-510
- Sleep, sedentary behavior, physical activity, and cardiovascular health: MESA.Med Sci Sport Exerc. 2021; 53: 724-731
- Mortality risk reductions from substituting screen time by discretionary activities.Med Sci Sports Exerc. 2017; 49 (Published correction appears in Med Sci Sports Exerc. 2017;49(7):1501): 1111-1119
- Effects of reallocating time spent engaging in sedentary behavior and physical activity on mortality in older adults: ELSIA Study.Int J Environ Res Public Health. 2021; 18: 4336
- Mortality benefits for replacing sitting time with different physical activities.Med Sci Sports Exerc. 2015; 47: 1833-1840
- Sitting time, physical activity, and risk of mortality in adults.J Am Coll Cardiol. 2019; 73 (Published correction appears in J Am Coll Cardiol. 2019;73(21):2789): 2062-2072
- Displacing sedentary time: association with cardiovascular disease prevalence.Med Sci Sport Exerc. 2016; 48: 641-647
- Effects of substituting sedentary time with physical activity on metabolic risk.Med Sci Sports Exerc. 2014; 46: 1946-1950
- Objectively measured sedentary time may predict insulin resistance independent of moderate-and vigorous-intensity physical activity.Diabetes. 2009; 58: 1776-1779
- Replacing sitting time with standing or stepping: associations with cardio-metabolic risk biomarkers.Eur Heart J. 2015; 36: 2643-2649
- Effects of high-intensity interval training compared to moderate-intensity continuous training on maximal oxygen consumption and blood pressure in healthy men: a randomized controlled trial.Biomedica. 2019; 39: 524-536
Article info
Publication history
Footnotes
Grant Support: The study was supported by grants from the National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024), National Institute of Diabetes and Digestive and Kidney Diseases (DK115679, DK091718, DK100383), Fogarty International Center (TW010790), and Tulane Research Centers of Excellence Awards. Xiang Li was a recipient of the American Heart Association Predoctoral Fellowship Award (19PRE34380036).