Abstract
Objective
To characterize the epidemiological trends and mortality of cutaneous lupus erythematosus
(CLE) between 1976 and 2018 in Olmsted County, Minnesota.
Patients and Methods
In this retrospective population-based cohort study, all incident and prevalent CLE
cases among adult residents in Olmsted County, Minnesota, between January 1, 1976,
and December 31, 2018, were identified and categorized by subtype through medical
record review using the resources of the Rochester Epidemiology Project.
Results
The overall incidence rate of CLE between 1976 and 2018 was 3.9 (95% CI, 3.4 to 4.5)
per 100,000. The incidence of CLE was relatively stable, with no major trend across
sexes or age groups. The age- and sex-adjusted prevalence of CLE was 108.9 per 100,000
on January 1, 2015. Mortality in CLE patients was similar to that of the general population,
with a standardized mortality ratio of 1.23 (95% CI, 0.88 to 1.66) with no observed
trends in mortality over time.
Conclusion
In the past 4 decades, the incidence of CLE remained stable. Patients with CLE have
mortality comparable to that of the general population.
Abbreviations and Acronyms:
CCLE (chronic cutaneous lupus erythematosus), CHLE (chilblain lupus), CLE (cutaneous lupus erythematosus), DLE (discoid lupus erythematosus), LP (lupus panniculitis), REP (Rochester Epidemiology Project), SCLE (subacute cutaneous lupus erythematosus), SLE (systemic lupus erythematosus), SMR (standardized mortality ratio), TL (tumid lupus)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 05, 2022
Footnotes
Grant Support: The Lupus Midwest Network (LUMEN) project is supported by the Centers for Disease Control and Prevention of the US Department of Health and Human Services under grant number U01 DP006491 as part of a financial assistance award totaling $1,750,000 with 100% funded by the Centers for Disease Control and Prevention/Department of Health and Human Services. The Rochester Epidemiology Project was supported by the National Institute on Aging of the National Institutes of Health under award number R01AG034676 and grant number UL1 TR002377 from the National Center for Advancing Translational Sciences, a component of the National Institutes of Health. This project was funded in part by the career enhancement award in women’s health research, Mayo Clinic Center for Women’s Health, and the Mayo Clinic Women’s Health Research Center.
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© 2022 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
