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Coronary Artery Bypass Grafting in Octogenarians—Risks, Outcomes, and Trends in 1283 Consecutive Patients



      To describe the risks, outcomes, and trends in patients older than 80 years undergoing coronary artery bypass grafting (CABG).


      We retrospectively studied 1283 consecutive patients who were older than 80 years and underwent primary isolated CABG from January 1, 1993, to October 31, 2019, in our clinic. Kaplan-Meier survival probability and quartile estimates were used to analyze patients’ survival. Logistic regression models were used for analyzing temporal trends in CABG cases and outcomes. A multivariable Cox proportional hazards regression model was developed to study risk factors for mortality.


      Operative mortality was overall 4% (n=51) but showed a significant decrease during the study period (P=.015). Median follow-up was 16.7 (interquartile range, 10.3-21.1) years, and Kaplan-Meier estimated survival rates at 1 year, 5 years, 10 years, and 15 years were 90.2%, 67.9%, 31.1%, and 8.2%, respectively. Median survival time was 7.6 years compared with 6.0 years for age- and sex-matched octogenarians in the general US population (P<.001). Multivariable Cox regression analysis identified older age (P<.001), recent atrial fibrillation or flutter (P<.001), diabetes mellitus (P<.001), smoking history (P=.006), cerebrovascular disease (P=.04), immunosuppressive status (P=.01), extreme levels of creatinine (P<.001), chronic lung disease (P=.02), peripheral vascular disease (P=.02), decreased ejection fraction (P=.03) and increased Society of Thoracic Surgeons predicted risk score (P=.01) as significant risk factors of mortality.


      Although CABG in octogenarians carries a higher surgical risk, it may be associated with favorable outcomes and increase in long-term survival. Further studies are warranted to define subgroups benefiting more from surgical revascularization.

      Abbreviations and Acronyms:

      BIMA (bilateral internal mammary artery), CABG (coronary artery bypass grafting), IQR (interquartile range), LAD (left anterior descending artery), LIMA (left internal mammary artery), MI (myocardial infarction), PCI (percutaneous coronary intervention), STS (Society of Thoracic Surgeons), SVG (saphenous vein graft), SWI (sternal wound infection)
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