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Correspondence: Address to Yasuhiko Hamada, MD, PhD, Department of Gastroenterology and Hepatology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507 Japan.
A woman between 70 and 80 years of age with a history of cervical cancer presented with changes in bowel habit. The patient took prednisolone for cardiac sarcoidosis. Colonoscopy revealed a 20-mm flat, whitish lesion with diffuse reddish speckles in the lower rectum (Figure 1). Based on the medical history and endoscopic findings, we suspected rectal condyloma acuminatum. However, biopsy results could not provide a definitive diagnosis; thus, we performed endoscopic submucosal dissection for excisional biopsy. The resected specimen revealed squamous epithelial cells with vacuolated cytoplasm (Figure 2). P16 staining, a marker of human papillomavirus infection, was diffusely stained. A final diagnosis of condyloma acuminatum was made. The patient was discharged uneventfully. No recurrence was observed 8 months after treatment.
Figure 1Colonoscopy revealing a 20-mm flat, whitish lesion in the lower rectum.
Condyloma acuminatum is a viral wart caused by human papillomavirus infection and can also be observed in immunocompromised patients, such as those taking immunosuppressive agents. Generally, condyloma acuminatum is detected in the perineum, labia, vagina, penis, perianal area, and anal canal. However, it rarely crosses the dentate line to grow into the rectum. Condyloma acuminatum has malignant potential, often developing into atypical epithelium or carcinoma; thus, surgical resection is the first-line treatment. However, recent reports have shown the efficacy of endoscopic submucosal dissection as a curative, minimally invasive option.
Long-term relapse-free treatment with endoscopic submucosal dissection combined with magnifying narrow-band imaging for a pregnant patient with flat-type condyloma acuminatum: a case report.
There is no consensus on surveillance of rectal condyloma acuminatum; thus, it is reasonable to apply the surveillance recommendations for anal condyloma acuminatum, with follow-ups every 6 to 12 months.
Long-term relapse-free treatment with endoscopic submucosal dissection combined with magnifying narrow-band imaging for a pregnant patient with flat-type condyloma acuminatum: a case report.
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