Abstract
Objective
To examine associations between physical activity (PA), inflammation, coronary artery
calcification (CAC), and incident coronary heart disease (CHD) in African Americans.
Methods
Among Jackson Heart Study participants without prevalent CHD at baseline (n=4295),
we examined the relationships between PA and high-sensitivity C-reactive protein,
the presence of CAC (Agatston score ≥100), and incident CHD. Based on the American
Heart Association’s Life’s Simple 7 metrics, participants were classified as having
poor, intermediate, or ideal PA.
Results
After adjustment for possible confounding factors, ideal PA was associated with lower
high-sensitivity C-reactive protein levels (β, −0.15; 95% CI, −0.15 to −0.002) and
a lower prevalence of CAC (odds ratio, 0.70; 95% CI, 0.51-0.96) compared with poor
PA. During a median of 12.8 years of follow-up, there were 164 incident CHD events
(3.3/1000 person-years). Ideal PA was associated with a lower rate of incident CHD
compared with poor PA (hazard ratio, 0.55; 95% CI, 0.31-0.98).
Conclusion
In a large community-based African American cohort, ideal PA was associated with lower
inflammation levels, a lower prevalence of CAC, and a lower rate of incident CHD.
These findings suggest that promotion of ideal PA may be an important way to reduce
the risk of subclinical and future clinical CHD in African Americans.
Abbreviations and Acronyms:
AHA (American Heart Association), BMI (body mass index), CAC (coronary artery calcification), CHD (coronary heart disease), CV (cardiovascular), hs-CRP (high-sensitivity C-reactive protein), JHS (Jackson Heart Study), PA (physical activity)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: March 10, 2021
Footnotes
For editorial comment see page 844
Grant Support: The Jackson Heart Study is supported by and conducted in collaboration with Jackson State University (HHSN268201800013I), Tougaloo College (HHSN268201800014I), Mississippi State Department of Health (HHSN268201800015I), and University of Mississippi Medical Center (HHSN268201800010I, HHSN268201800011I, and HHSN268201800012I) contracts from the National Heart, Lung, and Blood Institute and the National Institute on Minority Health and Health Disparities. Michael Hall has received funding from the National Institute of Diabetes and Digestive and Kidney Diseases (1K08DK099415-01A1) and the National Institute of General Medical Sciences (5U54GM115428 and P20GM104357).
Potential Competing Interests: The authors report no competing interests.
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© 2020 Mayo Foundation for Medical Education and Research
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Access this article on ScienceDirectLinked Article
- Physical Activity: Necessary, But Not Adequate Alone, to Overcome Disparities in Cardiovascular Disease in African AmericansMayo Clinic ProceedingsVol. 96Issue 4
- PreviewThe higher cardiovascular disease (CVD) morbidity and mortality in African Americans (AAs) is caused by numerous physiological, environmental, and socioeconomic factors. In addition, physical activity (PA) has been demonstrated to have significant cardiovascular health benefits.1 However, the impact of physical inactivity on diverse CVD in AAs must be contextualized within other risk factors and the social determinants of health (SDoH).
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