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Exclusion of Older Adults in COVID-19 Clinical Trials

      The coronavirus disease 2019 (COVID-19) pandemic has resulted in the infection of millions around the world.
      • Calgary O.
      Provisional COVID-19 Death Counts by Sex, Age, and State | Data | Centers for Disease Control and Prevention. Data. CDC.gov.
      ,
      CDC. COVID View
      Key Updates for Week 26. Centers for Disease Control and Prevention. Published July 3, 2020.
      The majority of COVID-19 hospitalizations and related deaths have been reported in older patients.
      • Calgary O.
      Provisional COVID-19 Death Counts by Sex, Age, and State | Data | Centers for Disease Control and Prevention. Data. CDC.gov.
      ,
      CDC. COVID View
      Key Updates for Week 26. Centers for Disease Control and Prevention. Published July 3, 2020.
      As such, it is crucial for COVID-19–related trials to enroll representative patients, and to be inclusive of older patients to generate valid and generalizable results. Here, we analyze the age inclusion/exclusion criteria of current COVID-19 trials, and the enrolled participants' ages among reported trials. We performed a data query of the ClinicalTrials.gov registry for trials regarding COVID-19 on June 8, 2020 (Figure).
      • Kouzy R.
      • Jaoude J.A.
      • Garcia C.J.G.
      • Alam M.B.E.
      • Taniguchi C.M.
      • Ludmir E.B.
      Characteristics of the multiplicity of randomized clinical trials for coronavirus disease 2019 launched during the pandemic.
      We identified trials with an upper age exclusion criterion. We also identified trials with reported results, and analyzed the age of included patients.
      Figure thumbnail gr1
      FigureFlowchart of screening, eligibility, and inclusion of coronavirus disease 2019 (COVID-19) clinical trials.
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      References

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        Provisional COVID-19 Death Counts by Sex, Age, and State | Data | Centers for Disease Control and Prevention. Data. CDC.gov.
        • CDC. COVID View
        Key Updates for Week 26. Centers for Disease Control and Prevention. Published July 3, 2020.
        • Kouzy R.
        • Jaoude J.A.
        • Garcia C.J.G.
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        Characteristics of the multiplicity of randomized clinical trials for coronavirus disease 2019 launched during the pandemic.
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