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Cardiorespiratory Fitness and Gray Matter Volume in the Temporal, Frontal, and Cerebellar Regions in the General Population

      Abstract

      Objective

      To analyze the association between cardiorespiratory fitness (CRF) and global and local brain volumes.

      Participants and Methods

      We studied 2103 adults (21-84 years old) from 2 independent population-based cohorts (Study of Health in Pomerania, examinations from June 25, 2008, through September 30, 2012). Cardiorespiratory fitness was measured using peak oxygen uptake (VO2peak), oxygen uptake at the anaerobic threshold (VO2@AT), and maximal power output from cardiopulmonary exercise testing on a bicycle ergometer. Magnetic resonance imaging brain data were analyzed by voxel-based morphometry using regression models with adjustment for age, sex, education, smoking, body weight, systolic blood pressure, glycated hemoglobin level, and intracranial volume.

      Results

      Volumetric analyses revealed associations of CRF with gray matter (GM) volume and total brain volume. After multivariable adjustment, a 1–standard deviation increase in VO2peak was related to a 5.31 cm³ (95% CI, 3.27 to 7.35 cm³) higher GM volume. Whole-brain voxel-based morphometry analyses revealed significant positive relations between CRF and local GM volumes. The VO2peak was strongly associated with GM volume of the left middle temporal gyrus (228 voxels), the right hippocampal gyrus (146 voxels), the left orbitofrontal cortex (348 voxels), and the bilateral cingulate cortex (68 and 43 voxels).

      Conclusion

      Cardiorespiratory fitness was positively associated with GM volume, total brain volume, and specific GM and white matter clusters in brain areas not primarily involved in movement processing. These results, from a representative population sample, suggest that CRF might contribute to improved brain health and might, therefore, decelerate pathology-specific GM decrease.

      Abbreviations and Acronyms:

      AAL (automated anatomical labeling), CAT12 (Computational Anatomy Toolbox 12), CPET (cardiopulmonary exercise testing), CRF (cardiorespiratory fitness), FWE (familywise error), GM (gray matter), MRI (magnetic resonance imaging), Ppeak,FWE (familywise error–corrected peak-level P), SD (standard deviation), SHIP (Study of Health in Pomerania), TBV (total brain volume), VBM (voxel-based morphometry), [email protected] (oxygen uptake at the anaerobic threshold), VO2peak (peak oxygen uptake), WM (white matter), Wmax (maximal power output)
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      Linked Article

      • Cardiorespiratory Fitness and Brain Volumes
        Mayo Clinic ProceedingsVol. 95Issue 1
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          The role of exercise and brain health has been a very popular topic of discussion in recent years. The National Academies of Sciences concluded that aerobic exercise may be useful in slowing cognitive changes in aging, and the Lancet Commission similarly reported the value of aerobic training and cognitive outcomes.1,2 In addition, the World Health Organization endorsed exercise as a means of intervening on the progression of cognitive impairment.3 In an evidence-based medicine review of the literature, the American Academy of Neurology concluded that exercise may be useful in slowing clinical progression from mild cognitive impairment to dementia.
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