Abbreviations and Acronyms:AS (aortic stenosis), AV (aortic valve), AVC (aortic valve calcification), CAD (coronary artery disease), EPC (endothelial progenitor cell), EPC-OCN (endothelial progenitor cell with osteoblastic phenotype), KDR (kinase insert domain receptor), TVI (time-velocity integral), VEGF (vascular endothelial growth factor), VIC (valvular interstitial cells)
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Burden of valvular heart diseases: a population-based study.Lancet. 2006; 368: 1005-1011
- Calcific aortic valve disease: a consensus summary from the alliance of investigators on calcific aortic valve disease.Arterioscler Thromb Vasc Biol. 2014; 34: 2387-2393
- Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group: executive summary: calcific aortic valve disease-2011 update.Circulation. 2011; 124: 1783-1791
- The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology.Am J Pathol. 2007; 171: 1407-1418
- Cellular mechanisms of aortic valve calcification.Circ Cardiovasc Interv. 2012; 5: 605-614
- Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis.Cardiovasc Pathol. 2005; 14: 80-87
- Identification and characterization of cells with high angiogenic potential and transitional phenotype in calcific aortic valve.Exp Cell Res. 2007; 313: 2326-2335
- Role of circulating osteogenic progenitor cells in calcific aortic stenosis.J Am Coll Cardiol. 2012; 60: 1945-1953
- Osteocalcin positive cd133+/cd34-/kdr+ progenitor cells as an independent marker for unstable atherosclerosis.Eur Heart J. 2012; 33: 2963-2969
- Coronary endothelial dysfunction in humans is associated with coronary retention of osteogenic endothelial progenitor cells.Eur Heart J. 2010; 31: 2909-2914
- Endothelial progenitor cells: mobilization, differentiation, and homing.Arterioscler Thromb Vasc Biol. 2003; 23: 1185-1189
- AC133, a novel marker for human hematopoietic stem and progenitor cells.Blood. 1997; 90: 5002-5012
- Differentiation and expansion of endothelial cells from human bone marrow CD133+ cells.Br J Haematol. 2001; 115: 186-194
- 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.J Am Coll Cardiol. 2014; 63: e57-e185
- Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis.J Am Coll Cardiol. 2008; 52: 1314-1325
- Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis.Int J Cardiol. 2015; 181: 57-64
- Valvular osteoclasts in calcification and aortic valve stenosis severity.Int J Cardiol. 2013; 168: 2264-2271
- Real-time imaging required for optimal echocardiographic assessment of aortic valve calcification.Clin Physiol Funct Imaging. 2012; 32: 470-475
- Human aortic valve calcification is associated with an osteoblast phenotype.Circulation. 2003; 107: 2181-2184
- Bone formation and inflammation in cardiac valves.Circulation. 2001; 103: 1522-1528
- Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis.J Am Coll Cardiol. 2004; 43: 1670-1676
- Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair.Eur Heart J. 2009; 30: 346-355
For editorial comment, see page 567
Grant Support: This study was supported by the National Institutes of Health (NIH) (grants AG31750 , DK102325 , HL92954 , and HL007111 ) and the Mayo Clinic Foundation. This publication was made possible by Clinical and Translational Science Award grant UL1 TR002377 from the National Center for Advancing Translational Sciences , a component of the NIH. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the NIH.
Potential Competing Interests: The authors report no competing interests.