A woman with diabetic retinopathy and a history of insulin-dependent diabetes mellitus (type 1) since childhood underwent mastectomy for breast cancer. In addition to the ductal carcinoma of the breast, the breast parenchyma had marked fibrosis with changes of diabetic mastopathy.
Diabetic mastopathy occurs most often in which clinical setting?
- a.Men with adult-onset type 2 diabetes mellitus
- b.Women with adult-onset type 2 diabetes mellitus
- c.Men with juvenile-onset type 1 insulin-dependent diabetes mellitus
- d.Women with juvenile-onset type 1 insulin-dependent diabetes mellitus
Answer: d. Women with juvenile-onset type 1 insulin-dependent diabetes mellitus
Diabetic mastopathy is most common in women with juvenile-onset type 1 insulin-dependent diabetes mellitus.
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Individuals often have other complications of diabetes such as diabetic retinopathy.1
Grossly, the tissue is firm and the cut surface appears white to gray and may be trabeculated.1
Histologically, the tissue appears fibrotic with collagenous stroma and increased stromal spindle cells.2
Perivascular, periductal, and lobular lymphoid infiltrates are often present.2
References
- Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes melliitus.Lancet. 1984; 1: 193-195
- Diabetic mastopathy: a clinicopathologic study in palpable and nonpalpable breast lesions.Mod Pathol. 1995; 8: 349-354
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Potential Competing Interests: The authors report no competing interests.
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© 2018 Mayo Foundation for Medical Education and Research
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