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Diabetic Mastopathy

      A woman with diabetic retinopathy and a history of insulin-dependent diabetes mellitus (type 1) since childhood underwent mastectomy for breast cancer. In addition to the ductal carcinoma of the breast, the breast parenchyma had marked fibrosis with changes of diabetic mastopathy.
      Diabetic mastopathy occurs most often in which clinical setting?
      • a.
        Men with adult-onset type 2 diabetes mellitus
      • b.
        Women with adult-onset type 2 diabetes mellitus
      • c.
        Men with juvenile-onset type 1 insulin-dependent diabetes mellitus
      • d.
        Women with juvenile-onset type 1 insulin-dependent diabetes mellitus
      Answer: d. Women with juvenile-onset type 1 insulin-dependent diabetes mellitus
      Diabetic mastopathy is most common in women with juvenile-onset type 1 insulin-dependent diabetes mellitus.
      • Soler N.G.
      • Khardori R.
      Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes melliitus.
      Individuals often have other complications of diabetes such as diabetic retinopathy.
      • Soler N.G.
      • Khardori R.
      Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes melliitus.
      Grossly, the tissue is firm and the cut surface appears white to gray and may be trabeculated.
      • Soler N.G.
      • Khardori R.
      Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes melliitus.
      Histologically, the tissue appears fibrotic with collagenous stroma and increased stromal spindle cells.
      • Morgan M.C.
      • Weaver M.G.
      • Crowe J.P.
      • Abdul-Karim F.W.
      Diabetic mastopathy: a clinicopathologic study in palpable and nonpalpable breast lesions.
      Perivascular, periductal, and lobular lymphoid infiltrates are often present.
      • Morgan M.C.
      • Weaver M.G.
      • Crowe J.P.
      • Abdul-Karim F.W.
      Diabetic mastopathy: a clinicopathologic study in palpable and nonpalpable breast lesions.

      References

        • Soler N.G.
        • Khardori R.
        Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes melliitus.
        Lancet. 1984; 1: 193-195
        • Morgan M.C.
        • Weaver M.G.
        • Crowe J.P.
        • Abdul-Karim F.W.
        Diabetic mastopathy: a clinicopathologic study in palpable and nonpalpable breast lesions.
        Mod Pathol. 1995; 8: 349-354