- Minnesota Department of Health
Abbreviations and Acronyms:AASM (American Academy of Sleep Medicine), AHI (apnea-hypopnea index), CPAP (continuous positive airway pressure), DEA (Drug Enforcement Agency), FDA (Food and Drug Administration), MDH (Minnesota Department of Health), OSA (obstructive sleep apnea), THC (tetrahydrocannabinol)
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- Minnesota Medical Cannabis Program petition to add a medically qualifying condition.http://www.health.state.mn.us/topics/cannabis/rulemaking/petitionOSA.pdfDate accessed: March 20, 2018
- Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat.Respir Physiol Neurobiol. 2014; 190: 20-24
- Effects of cannabinoid agonists and antagonists on sleep and breathing in Sprague-Dawley rats.Sleep. 2017; 40https://doi.org/10.1093/sleep/zsx112
- Proof of concept trial of dronabinol in obstructive sleep apnea.Front Psychiatry. 2013; 4: 1
- Pharmacotherapy of apnea by cannabimimetic enhancement, the PACE clinical trial: effects of dronabinol in obstructive sleep apnea.Sleep. 2018; 41https://doi.org/10.1093/sleep/zsx184
- Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults.J Clin Sleep Med. 2009; 5: 263-276
Ramar K, Rosen IM, Kirsch DB, et al; American Academy of Sleep Medicine Board of Directors. Medical cannabis and the treatment of obstructive sleep apnea: an American Academy of Sleep Medicine position statement [published online ahead of print March 30, 2018]. J Clin Sleep Med.
- Effect of delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults.J Clin Psychopharmacol. 2004; 24: 305-313
- Marinol (dronabinol) capsules.https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/018651s021lbl.pdfDate accessed: April 1, 2018
- Marijuana use and motor vehicle crashes.Epidemiol Rev. 2012; 34: 65-72
- Medicinal delta(9)-tetrahydrocannabinol (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in Standard Field Sobriety Tests.Addiction. 2012; 107: 1837-1844
- Clinical utility of dronabinol in the treatment of weight loss associated with HIV and AIDS.HIV/AIDS (Auckl). 2016; 8: 37-45
- GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.BMJ. 2008; 336: 924-926
Potential Competing Interests: Dr Mansukhani was the principal investigator (PI) on industry grant (ResMed Corp) 2016-2018 and the PI on benefactor-sponsored career development award at Mayo Clinic (2017-2019). She was also a speaker at the CME conference-ARCS sleep conference 2016. Dr Olson has board membership of the American Academy of Sleep Medicine and is author for 3 sections of UpToDate regarding obstructive sleep apnea and perioperative care. Dr St Louis received consultancy fees from Axovant consultancy; has grants/grants pending from the National Institutes of Health and the Michael J. Fox Foundation; and receives royalties from Wiley Blackwell for the book Epilepsy and the Interictal State: Co-Morbidities and Quality of Life. The rest of the authors report no competing interests.
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- Comment on Medical Cannabis for Obstructive Sleep Apnea: Premature and Potentially HarmfulMayo Clinic ProceedingsVol. 93Issue 11
- PreviewWe recently read with interest “Medical cannabis for obstructive sleep apnea: premature and potentially harmful” by Kolla et al1 competently summarizing the current evidence for the recent approval of obstructive sleep apnea as a certifying condition for the use of medical cannabis in the state of Minnesota. We share the authors’ doubt to the scientific validity of this recent action. It would be helpful for the readers of Mayo Clinic Proceedings to know additional background relating to the evolving medical and legislative landscape of medical cannabis.