Abstract
Objective
To examine the prospective relationships among cardiorespiratory fitness (CRF), fasting
blood triglyceride to high density lipoprotein cholesterol ratio (TG:HDL-C), and coronary
heart disease (CHD) mortality in men.
Methods
A total of 40,269 men received a comprehensive baseline clinical examination between
January 1, 1978, and December 31, 2010. Their CRF was determined from a maximal treadmill
exercise test. Participants were divided into CRF categories of low, moderate, and
high fit by age group and by TG:HDL-C quartiles. Hazard ratios for CHD mortality were
computed using Cox regression analysis.
Results
A total of 556 deaths due to CHD occurred during a mean ± SD of 16.6±9.7 years (669,678
man-years) of follow-up. A significant positive trend in adjusted CHD mortality was
shown across decreasing CRF categories (P for trend<.01). Adjusted hazard ratios were significantly higher across increasing
TG:HDL-C quartiles as well (P for trend<.01). When grouped by CRF category and TG:HDL-C quartile, there was a significant
positive trend (P=.04) in CHD mortality across decreasing CRF categories in each TG:HDL-C quartile.
Conclusion
Both CRF and TG:HDL-C are significantly associated with CHD mortality in men. The
risk of CHD mortality in each TG:HDL-C quartile was significantly attenuated in men
with moderate to high CRF compared with men with low CRF. These results suggest that
assessment of CRF and TG:HDL-C should be included for routine CHD mortality risk assessment
and risk management.
Abbreviations and Acronyms:
BMI (body mass index), CCLS (Cooper Center Longitudinal Study), CHD (coronary heart disease), CRF (cardiorespiratory fitness), CVD (cardiovascular disease), HDL-C (high-density lipoprotein cholesterol), HR (hazard ratio), LDL-C (low-density lipoprotein cholesterol), MET (metabolic equivalent), NHANES (National Health and Nutrition Examination Survey), TG:HDL-C (fasting triglyceride to high-density lipoprotein cholesterol ratio)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 17, 2017
Footnotes
For editorial comment, see page 1743; for a related article, see page 1753
Grant Support: The Cooper Institute, a 501(c)(3) nonprofit research institute, provided internal funding for this study.
Identification
Copyright
© 2017 Mayo Foundation for Medical Education and Research
