Abstract
Objective
To assess the 6-month effectiveness of ultrasound-guided perineural injection therapy
(PIT) using 5% dextrose (D5W) in patients with mild-to-moderate carpal tunnel syndrome
(CTS).
Patients and Methods
A prospective, randomized, placebo-controlled, and double-blind study was conducted
between May 1, 2016, through March 30, 2017. A total of 49 participants diagnosed
with mild-to-moderate CTS were randomized into D5W and control groups. Participants
in the D5W group received 1 session of ultrasound-guided PIT with 5 cc of D5W, and
the control group received PIT with normal saline. The visual analog scale measured
pain as a primary outcome. Secondary outcomes were Boston Carpal Tunnel Syndrome Questionnaire
scores, the cross-sectional area of the median nerve, and electrophysiological measurement
results. Assessment was performed before injection and at 1, 3, and 6 months post-injection.
Results
All patients (data from 30 wrists in each group) completed the study. Compared with
the control group, at all post-injection time points, the D5W group had a significant
reduction in pain and disability, improvement on electrophysiological response measures,
and decreased cross-sectional area of the median nerve.
Conclusion
Our study reveals that ultrasound-guided PIT with D5W is an effective treatment for
patients with mild-to-moderate CTS.
Trial Registration
Abbreviations and Acronyms:
BCTQ (Boston Carpal Tunnel Syndrome Questionnaire), CSA (cross-sectional area), CTS (carpal tunnel syndrome), D5W (5% dextrose), DML (distal motor latency), MN (median nerve), PIT (perineural injection therapy), SNCV (sensory nerve conduction velocity), VAS (visual analog scale)To read this article in full you will need to make a payment
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Article Info
Footnotes
For editorial comment, see page 1173
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