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Gastric Signet Ring Cell Carcinoma

      This subtotal gastrectomy specimen has a thickened antral rugal fold (arrow) indicating an area of signet ring cell carcinoma. The tumor was confined to the mucosa.
      Which statement is most accurate about gastric cancer?
      • a.
        Gastric cancer is the second most common type of cancer worldwide
      • b.
        The widespread use of upper gastrointestinal tract endoscopy has had no effect on the on the detection of superficial gastric cancers
      • c.
        Even early gastric cancers are uniformly fatal
      • d.
        Signet ring cell carcinomas are classified as tubal or intestinal-type gastric cancer
      Answer: a. Gastric cancer is the second most common type of cancer worldwide.
      The widespread use of upper gastrointestinal tract endoscopy has increased the frequency of detection of superficial gastric cancers.
      • Dinis-Ribeiro M.
      • Areia M.
      • de Vries A.C.
      • et al.
      Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED).
      Gastric cancer is considered potentially curable if detected early. Early gastric cancers are confined to the mucosa or submucosa. Signet ring cell carcinomas are a poorly cohesive type of gastric cancer.
      Microscopy shows tumor cells in the mucosa that are single cells (arrow) with distended cytoplasm and compressed eccentric nuclei.

      Reference

        • Dinis-Ribeiro M.
        • Areia M.
        • de Vries A.C.
        • et al.
        Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED).
        Endoscopy. 2012; 44: 74-94