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Atherogenic Index of Plasma and Triglyceride/High-Density Lipoprotein Cholesterol Ratio Predict Mortality Risk Better Than Individual Cholesterol Risk Factors, Among an Older Adult Population

      Atherogenic index of plasma (AIP), a logarithmically transformed ratio of triglycerides (TGs)/high-density lipoprotein cholesterol (HDL-C), is considered a marker of plasma atherogenicity
      • Dobiásová M.
      AIP–atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice.
      based on observed strong ( r>.7), positive associations between AIP and cholesterol esterification rates, lipoprotein particle size, and remnant lipoproteinemia.
      • Dobiásová M.
      • Frohlich J.
      The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)).
      • Quispe R.
      • Manalac R.J.
      • Faridi K.F.
      • et al.
      Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: the Very Large Database of Lipids-4 (VLDL-4) study.
      Previous work supports the utility of this parameter, demonstrating its positive association with cardiovascular disease (CVD) risk.
      • Bhardwaj S.
      • Bhattacharjee J.
      • Bhatnagar M.
      • Tyagi S.
      Atherogenic index of plasma, castelli risk index and atherogenic coefficient—new parameters in assessing cardiovascular risk.
      • Essiarab F.
      • Taki H.
      • Lebrazi H.
      • Sabri M.
      • Saïle R.
      Usefulness of lipid ratios and atherogenic index of plasma in obese Moroccan women with or without metabolic syndrome.
      Notably, evidence indicates that AIP may be more closely associated with CVD risk than are other atherogenic indices
      • Bhardwaj S.
      • Bhattacharjee J.
      • Bhatnagar M.
      • Tyagi S.
      Atherogenic index of plasma, castelli risk index and atherogenic coefficient—new parameters in assessing cardiovascular risk.
      or individual lipoproteins cholesterol concentrations alone.
      • Essiarab F.
      • Taki H.
      • Lebrazi H.
      • Sabri M.
      • Saïle R.
      Usefulness of lipid ratios and atherogenic index of plasma in obese Moroccan women with or without metabolic syndrome.
      The purpose of the present study was to assess whether the predictive value of AIP extended to mortality risk among a sample of older US adults, when compared with individual cholesterol risk factors (eg, triglycerides, total cholesterol [TC], low-density lipoprotein cholesterol (LDL-C), and HDL-C) or the TG/HDL-C ratio.
      • Quispe R.
      • Manalac R.J.
      • Faridi K.F.
      • et al.
      Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: the Very Large Database of Lipids-4 (VLDL-4) study.
      This has yet to be evaluated in the literature and is a worthwhile investigation, considering that CVD remains the leading cause of mortality among US adults.
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      References

        • Dobiásová M.
        AIP–atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice.
        Vnitr Lek. 2006; 52 ([in Czech]): 64-71
        • Dobiásová M.
        • Frohlich J.
        The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)).
        Clin Biochem. 2001; 34: 583-588
        • Quispe R.
        • Manalac R.J.
        • Faridi K.F.
        • et al.
        Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: the Very Large Database of Lipids-4 (VLDL-4) study.
        Atherosclerosis. 2015; 242: 243-250
        • Bhardwaj S.
        • Bhattacharjee J.
        • Bhatnagar M.
        • Tyagi S.
        Atherogenic index of plasma, castelli risk index and atherogenic coefficient—new parameters in assessing cardiovascular risk.
        Int J Pharm Biol Sci. 2013; 3: 359-364
        • Essiarab F.
        • Taki H.
        • Lebrazi H.
        • Sabri M.
        • Saïle R.
        Usefulness of lipid ratios and atherogenic index of plasma in obese Moroccan women with or without metabolic syndrome.
        Ethn Dis. 2014; 24: 207-212