Abstract
The importance of cardiorespiratory fitness (CRF) is well established. This report
provides newly developed standards for CRF reference values derived from cardiopulmonary
exercise testing (CPX) using cycle ergometry in the United States. Ten laboratories
in the United States experienced in CPX administration with established quality control
procedures contributed to the “Fitness Registry and the Importance of Exercise: A
National Database” (FRIEND) Registry from April 2014 through May 2016. Data from 4494
maximal (respiratory exchange ratio, ≥1.1) cycle ergometer tests from men and women
(20-79 years) from 27 states, without cardiovascular disease, were used to develop
these references values. Percentiles of maximum oxygen consumption (VO2max) for men and women were determined for each decade from age 20 years through age
79 years. Comparisons of VO2max were made to reference data established with CPX data from treadmill data in the
FRIEND Registry and previously published reports. As expected, there were significant
differences between sex and age groups for VO2max (P<.01). For cycle tests within the FRIEND Registry, the 50th percentile VO2max of men and women aged 20 to 29 years declined from 41.9 and 31.0 mLO2/kg/min to 19.5 and 14.8 mLO2/kg/min for ages 70 to 79 years, respectively. The rate of decline in this cohort
was approximately 10% per decade. The FRIEND Registry reference data will be useful
in providing more accurate interpretations for the US population of CPX-measured VO2max from exercise tests using cycle ergometry compared with previous approaches based
on estimations of standard differences from treadmill testing reference values.
Abbreviations and Acronyms:
BMI (body mass index), CPX (cardiopulmonary exercise testing), CRF (cardiorespiratory fitness), CVD (cardiovascular disease), FRIEND (Fitness Registry and the Importance of Exercise: A National Database), VO2max (maximum oxygen consumption)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: December 07, 2016
Footnotes
Grant Support: Partial support for this project was provided by grant GS04T11BFP0001 (L.A.K.) from grant from TKC Global Solutions , LLC. The work was supported by grant UL1TR000050 (R.A.) from the National Center for Advancing Translational Sciences , National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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© 2016 Mayo Foundation for Medical Education and Research
