Abstract
Objective
To investigate the association between physical activity (PA) and risk of mortality
in a large middle-aged cohort stratified by inflammatory status.
Patients and Methods
A total of 336,560 individuals (mean age, 39.7 years; 58% male) who underwent comprehensive
health screenings were enrolled in this prospective cohort study. They were grouped
according to self-reported PA level using a questionnaire: no regular PA with a sedentary
lifestyle, regular but insufficient PA (below the guidelines), sufficient PA (concordant
with the guidelines), and health-enhancing PA. Inflammation was assessed via high-sensitivity
C-reactive protein (hsCRP) level. Study end points were all-cause, cardiovascular-related,
and cancer-related mortality.
Results
During the 1,976,882 person-years of follow-up (median follow-up duration, 6.17 years),
2062 deaths occurred. Compared with a sedentary lifestyle, the hazard ratios (95%
CIs) on the multivariable Cox proportional hazards regression analyses for all-cause
mortality by PA level were 0.95 (0.84-1.07), 0.85 (0.72-0.99), and 0.75 (0.60-0.93)
(P for trend=.003), and those for cardiovascular- and cancer-related mortality were
0.95, 0.80, and 0.55 (P for trend=.05) and 0.82, 0.83, and 0.78 (P for trend=.01), respectively. Compared with participants with low hsCRP levels and
any regular PA, those with high hsCRP levels and no regular PA had a significantly
higher risk of mortality (1.59 [1.38-1.84]).
Conclusion
Higher PA levels were associated with a dose-dependent reduced risk of cardiovascular-related,
cancer-related, and all-cause mortality. Individuals with high hsCRP levels and no
regular PA had the highest risk of mortality.
Abbreviations and Acronyms:
BMI (body mass index), BP (blood pressure), CVD (cardiovascular disease), HDL-C (high-density lipoprotein cholesterol), HOMA-IR (homeostatic model assessment of insulin resistance), HR (hazard ratio), hsCRP (high-sensitivity C-reactive protein), IPAQ-SF (International Physical Activity Questionnaire Short Form), IQR (interquartile range), LDL-C (low-density lipoprotein cholesterol), MET (metabolic equivalent), PA (physical activity)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: October 25, 2016
Footnotes
For editorial comment, see page 1675; for related articles, see pages 1680 and 1693
Identification
Copyright
© 2016 Mayo Foundation for Medical Education and Research
