Abstract
Objectives
To investigate the recent incidence of T1D in a US Midwestern county to determine
whether this increase has been sustained and compare it with the incidence of celiac
disease (CD) and also investigate the prevalence of CD, an associated autoimmune disease,
within the cohort.
Patients and Methods
A broad search strategy was used to identify all incident cases of T1D in Olmsted
County, Minnesota, between January 1, 1994, and December 31, 2010, using the Rochester
Epidemiology Project. Diagnosis and residency status were confirmed through the medical
record. Incidence rates were directly standardized to the 2010 US population. Poisson
regression was used to test for a change in incidence rate. Clinical charts were reviewed
to confirm case status.
Results
There were 233 incident cases of T1D. Directly adjusting for age and sex with respect
to the 2010 US white population, the overall annual incidence of T1D was 9.2 (95%
CI, 8.0-10.4) per 100,000 people per year among all ages and 19.9 (95% CI, 16.6-23.2)
per 100,000 people per year for those younger than 20 years. There was no significant
increase in the incidence of T1D over time (P=.45). Despite the overall stability in annual incidence, there was an initial increasing
trend followed by a plateau. Of the 109 patients with T1D (47%) tested for CD, 12%
(13) had biopsy-proven CD.
Conclusion
The incidence of T1D has stopped increasing in Olmsted County, Minnesota, in the most
recent decade. Further studies are needed to confirm this finding and explore reasons
for this plateau.
Abbreviations and Acronyms:
CD (celiac disease), LADA (latent autoimmune diabetes in adults), REP (Rochester Epidemiology Project), T1D (type 1 diabetes), T2D (type 2 diabetes)To read this article in full you will need to make a payment
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Article Info
Footnotes
Grant Support: This study was made possible by the Rochester Epidemiology Project (grant number R01-AG034676; Principal Investigator: Walter A. Rocca, MD, and Jennifer St Sauver, PhD). The work was also supported by grant DK85516 (Y.C.K.) from the National Institute of Diabetes and Digestive and Kidney Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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