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In Reply II—Risk of Disseminated Disease in Immunocompromised Patients Receiving Live Zoster Vaccine

      The case reported by Dr Young illustrates the potential for vaccine-related herpes zoster infections in highly immunosuppressed patients. In our original study published in the July 2015 issue of Mayo Clinic Proceedings,
      • Cheetham T.C.
      • Marcy S.M.
      • Tseng H.F.
      • et al.
      Risk of herpes zoster and disseminated varicella zoster in patients taking immunosuppressant drugs at the time of zoster vaccination.
      there were only 500 individuals who were receiving corticosteroid doses similar to the regimen reported in this case, and therefore, conclusions could not be drawn regarding the safety of the zoster vaccine in the population we described. The case reported by Dr Young highlights the need for caution or possibly withholding zoster vaccination in highly immunosuppressed patients.

      Reference

        • Cheetham T.C.
        • Marcy S.M.
        • Tseng H.F.
        • et al.
        Risk of herpes zoster and disseminated varicella zoster in patients taking immunosuppressant drugs at the time of zoster vaccination.
        Mayo Clin Proc. 2015; 90: 865-873

      Linked Article

      • Risk of Disseminated Disease in Immunosuppressed Patients Receiving Live Zoster Vaccine
        Mayo Clinic ProceedingsVol. 91Issue 7
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          I read with interest the letter by Bubb1 and the reply by Cheetham et al2 in the November 2015 issue of Mayo Clinic Proceedings regarding the risk of disseminated disease in immunosuppressed patients receiving live zoster vaccine. Although the vaccine has been found to be highly effective and there is a paucity of cases of vaccine-related infections, the following report serves to highlight the need for caution when immunizing highly immunosuppressed patients.
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