Abstract
Objective
To evaluate the association of aspirin and other nonsteroidal anti-inflammatory drugs
with the incidence of postmenopausal breast cancer for risk subgroups defined by selected
nonmodifiable or difficult to modify breast cancer risk factors in order to better
understand the potential risk-benefit ratio for targeted chemoprevention.
Patients and Methods
Postmenopausal women with no history of cancer on July 1, 1992 (N=26,580), were prospectively
followed up through December 31, 2005, for breast cancer incidence (N=1581). Risk
subgroups were defined on the basis of family history of breast cancer, age at menarche,
age at menopause, parity/age at first live birth, personal history of benign breast
disease, and body mass index. Hazard ratios (HRs) and 95% CIs adjusted for other breast
cancer risk factors were estimated using Cox models.
Results
Aspirin use was associated with a lower incidence of breast cancer for women with
a family history of breast cancer (HR, 0.62 for 6 or more times per week vs never
use; 95% CI, 0.41-0.93) and those with a personal history of benign breast disease
(HR, 0.69; 95% CI, 0.50-0.95) but not for women in higher-risk subgroups for age at
menarche, age at menopause, parity/age at first live birth, or body mass index. In
contrast, inverse associations with aspirin use were observed in all lower-risk subgroups.
Nonsteroidal anti-inflammatory drug use had no association with breast cancer incidence.
Conclusion
On the basis of their increased risk of breast cancer, postmenopausal women with a
family history of breast cancer or a personal history of benign breast disease could
potentially be targeted for aspirin chemoprevention studies. Future studies are needed
to confirm these findings.
Abbreviations and Acronyms:
BMI (body mass index), COX (cyclooxygenase), HR (hazard ratio), NNT (number needed to treat), NSAID (nonsteroidal anti-inflammatory drug), RR (relative risk)To read this article in full you will need to make a payment
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Article Info
Publication History
Published online: December 08, 2015
Footnotes
Grant Support: This work was supported by grant R01 CA39742 from the National Institutes of Health .
Identification
Copyright
© 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
