Abstract
Objective
To assess the risk of stroke and myocardial infarction (MI) after herpes zoster in
a US community population of older adults.
Patients and Methods
We performed a community cohort study (January 1, 1986, to October 1, 2011) comparing
the risk of stroke and MI in 4862 adult residents of Olmsted County, Minnesota, 50
years and older with and without herpes zoster and 19,433 sex- and age-matched individuals
with no history of herpes zoster. Odds ratios are presented for MI and stroke at 3,
6, 12, and 36 months after index herpes zoster plus hazard ratios for long-term risk
(up to 28.6 years).
Results
Individuals with herpes zoster had more risk or confounding factors for MI and stroke,
suggesting that they had worse health status overall. When controlling for the multiple
risk factors, those with herpes zoster were at increased risk for stroke at 3 months
after herpes zoster compared with those without a history of herpes zoster (odds ratio,
1.53; 95% CI, 1.10-2.33; P=.04). The association between herpes zoster and MI at 3 months was not robust across
analytic methods. Herpes zoster was not associated with an increased risk of stroke
or MI at any point beyond 3 months.
Conclusions
Herpes zoster was associated with only a short-term increased risk of stroke, which
may be preventable with the prevention of herpes zoster.
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Article info
Publication history
Published online: December 15, 2015
Footnotes
Grant Support: This study was supported by an investigator-initiated grant from Merck & Company (B.P.Y.), grant R01 AG034676 from the National Institute on Aging (B.P.Y.), and grant AG032958 from the National Institutes of Health (M.A.N., D.G.).
Role of the Funder/Sponsor: None of the funders or sponsors had any role in the design and conduct of the study, collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Identification
Copyright
© 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
