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In reply—Familial Transient Global Amnesia

      We thank Dr Dandapat and colleagues for their complimentary comments on our review and for sharing their clinical experience with us. As they correctly point out, there have been a few reports of familial clusters of transient global amnesia (TGA) cases.
      • Corston R.N.
      • Godwin-Austen R.B.
      Transient global amnesia in four brothers.
      • Davies R.R.
      • Larner A.J.
      Familial transient global amnesia.
      • Dupuis M.J.M.
      • Pierre P.
      • Gonsette R.E.
      Transient global amnesia and migraine in twin sisters.
      • Munro J.M.
      • Loizou L.A.
      Transient global amnesia—familial incidence.
      • Segers-van Rijn J.
      • de Bruijn S.F.T.M.
      Transient global amnesia: a genetic disorder [letter]?.
      • Stracciari A.
      • Rebucci G.G.
      Transient global amnesia and migraine: familial incidence.
      Given the relative infrequency of TGA, it is reasonable to consider that these familial clusters may not be just coincidental. Details provided on these familial cases have been sometimes incomplete, but we found that migraine was a comorbidity in at least one of the family members with TGA in 4 of the 6 familial cases reported in the literature.
      • Davies R.R.
      • Larner A.J.
      Familial transient global amnesia.
      • Dupuis M.J.M.
      • Pierre P.
      • Gonsette R.E.
      Transient global amnesia and migraine in twin sisters.
      • Segers-van Rijn J.
      • de Bruijn S.F.T.M.
      Transient global amnesia: a genetic disorder [letter]?.
      • Stracciari A.
      • Rebucci G.G.
      Transient global amnesia and migraine: familial incidence.
      Thus, a common genetic predisposition to migraine and TGA
      • Zorzon M.
      • Antonutti L.
      • Masè G.
      • Biasutti E.
      • Vitrani B.
      • Cazzato G.
      Transient global amnesia and transient ischemic attack: natural history, vascular risk factors, and associated conditions.
      • Lin K.H.
      • Chen Y.T.
      • Fuh J.L.
      • et al.
      Migraine is associated with a higher risk of transient global amnesia: a nationwide cohort study.
      could potentially explain familial aggregation. Further research will be necessary to clarify this possibility.

      References

        • Corston R.N.
        • Godwin-Austen R.B.
        Transient global amnesia in four brothers.
        J Neurol Neurosurg Psychiatry. 1982; 45: 375-377
        • Davies R.R.
        • Larner A.J.
        Familial transient global amnesia.
        Case Rep Neurol. 2012; 4: 236-239
        • Dupuis M.J.M.
        • Pierre P.
        • Gonsette R.E.
        Transient global amnesia and migraine in twin sisters.
        J Neurol Neurosurg Psychiatry. 1987; 50 ([letter]): 816-817
        • Munro J.M.
        • Loizou L.A.
        Transient global amnesia—familial incidence.
        J Neurol Neurosurg Psychiatry. 1982; 45 ([letter]): 1070
        • Segers-van Rijn J.
        • de Bruijn S.F.T.M.
        Transient global amnesia: a genetic disorder [letter]?.
        Eur Neurol. 2010; 63: 186-187
        • Stracciari A.
        • Rebucci G.G.
        Transient global amnesia and migraine: familial incidence.
        J Neurol Neurosurg Psychiatry. 1986; 49 ([letter]): 716
        • Zorzon M.
        • Antonutti L.
        • Masè G.
        • Biasutti E.
        • Vitrani B.
        • Cazzato G.
        Transient global amnesia and transient ischemic attack: natural history, vascular risk factors, and associated conditions.
        Stroke. 1995; 26: 1536-1542
        • Lin K.H.
        • Chen Y.T.
        • Fuh J.L.
        • et al.
        Migraine is associated with a higher risk of transient global amnesia: a nationwide cohort study.
        Eur J Neurol. 2014; 21: 718-724

      Linked Article

      • Familial Transient Global Amnesia
        Mayo Clinic ProceedingsVol. 90Issue 5
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          We acclaim the excellent, comprehensive review of transient global amnesia (TGA) by Arena and Rabinstein1 in the February 2015 issue of Mayo Clinic Proceedings. Considering the unknown pathophysiology of TGA, we note the authors make minimal mention of the possible contribution of genetics (on page 267). We request that the authors comment further on this possibility.
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