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Effect of Physical Activity Assessment on Prognostication for Peripheral Artery Disease and Mortality

Published:January 30, 2015DOI:https://doi.org/10.1016/j.mayocp.2014.12.016

      Abstract

      Objective

      To examine whether a simple question about the performance of regular vigorous activity is associated with peripheral artery disease (PAD) and mortality.

      Methods

      A total of 1288 individuals undergoing nonemergency coronary angiography were assessed for participation in regular vigorous activity by questionnaire. Data on demographic characteristics, ankle-brachial indexes, and cardiovascular outcomes were prospectively collected.

      Results

      Compared with those who denied participation in regular vigorous activity, those who reported participation were less likely to have PAD (odds ratio, 0.58; 95% CI, 0.39-0.86), had higher ankle-brachial indexes, had better Walking Impairment Questionnaire scores (P<.001), and experienced reduced all-cause mortality rates (hazard ratio, 0.48; 95% CI, 0.31-0.74). When added to the Framingham Risk Score, the response improved the net reclassification index for all-cause (32.6%) and cardiovascular (32.0%) mortality.

      Conclusion

      Among at-risk individuals, regular vigorous activity is associated with decreased PAD and all-cause mortality. Simple and readily available, a single yes/no query about participation in regular vigorous exercise could be used to improve risk stratification.

      Abbreviations and Acronyms:

      ABI (ankle-brachial index), CAD (coronary artery disease), NRI (net reclassification improvement), PAD (peripheral artery disease), WIQ (Walking Impairment Questionnaire)
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