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Association Between Alcohol Consumption and Risk of Cardiovascular Disease and All-Cause Mortality in Patients With Hypertension: A Meta-Analysis of Prospective Cohort Studies

      Abstract

      Objective

      To conduct a meta-analysis summarizing the risk of cardiovascular disease (CVD) and all-cause mortality (ACM) in relation to alcohol consumption in patients with hypertension, focusing on clarifying dose-response associations.

      Patients and Methods

      PubMed and EMBASE were searched for eligible prospective cohort studies from December 3, 1949, through January 18, 2014. The semi-parameter method and dose-response analysis were used.

      Results

      Nine studies (11 cohorts) were included in the meta-analysis. Compared with the lowest alcohol level (abstainers/occasional drinkers), the pooled relative risk (RR) was 0.72 (95% CI, 0.68-0.77) for the third highest category (median, 10 g/d), 0.81 (95% CI, 0.71-0.93) for the second highest category (median, 20 g/d), and 0.60 (95% CI, 0.54-0.67) for the highest category (median, 30 g/d). A J-shaped relationship between alcohol use and ACM was observed, and the nadir (RR, 0.82; 95% CI, 0.76-0.88) was found to be at a dose of 8 to 10 g of alcohol consumption per day.

      Conclusion

      Findings of this meta-analysis suggest that low-to-moderate alcohol consumption was inversely significantly associated with the risk of CVD and ACM in patients with hypertension.

      Abbreviations and Acronyms:

      ACM (all-cause mortality), CHD (coronary heart disease), CVD (cardiovascular disease), RR (relative risk)
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      Linked Article

      • Ethanol Should Be Subjected to a Randomized Controlled Trial
        Mayo Clinic ProceedingsVol. 90Issue 1
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          The meta-analysis by Huang et al1 in the September 2014 issue of Mayo Clinic Proceedings revealed an association between low to moderate ethanol consumption and reduced risk of cardiovascular disease and all-cause mortality (ACM) in hypertensive patients. This study adds additional observational evidence to support the hypothesis that there is a J-shaped curve for ACM vs ethanol consumption, with minimum ACM observed in persons with a low-level long-term ethanol intake of about 10 g/d (about 1 standard serving or drink).
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