Abbreviations and Acronyms:ASCT (autologous stem cell transplant), Edm (Edmonston), FDG (fluorodeoxyglucose), GFP (green fluorescent protein), M-protein (monoclonal protein), MM (multiple myeloma), MV (measles virus), MV-NIS (measles virus encoding human sodium iodide symporter), NIS (sodium iodide symporter), OV (oncolytic virus), PET (Positron emission tomography), PRN (plaque reduction neutralization), SPECT (single-photon emission computed tomography), TCID50 (50% tissue culture infectious dose)
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For editorial comment, see page 863
Grant Support: This work was supported by funds from the National Institutes of Health/National Cancer Institute (grants R01CA125614 and R01CA168719 ), Al and Mary Agnes McQuinn, the Harold W. Siebens Foundation, and the Richard M. Schulze Family Foundation. The National Cancer Institute RAID (Rapid Access to Intervention Development) Program supported MV-NIS manufacture and toxicology/pharmacology studies.
Potential Competing Interests: Drs Russell, Federspiel, and Peng and Mayo Clinic have a financial interest in the technology used in this research.