Abbreviations and Acronyms:APC ( annual percent change), CRC ( colorectal cancer), FAP ( familial adenomatous polyposis), FDR ( first-degree relative), HR ( hazard ratio), MSS ( microsatellite stable), PCP ( primary care physician), SEER ( Surveillance, Epidemiology, and End Results)
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Grant Support: This work was supported by the Colon Cancer Alliance and partially supported by the University of Texas MD Anderson Cancer Center G. S. Hogan Gastrointestinal Cancer Research Fund (Y.N.Y.).
Potential Competing Interests: Dr Ahnen serves on the scientific advisory boards of EXACT Sciences and CM&L Pharma. Dr Jones is a member of the Salix Pharmaceuticals speaker’s bureau and a partner in Premier Surgical Center, Louisville, KY. Dr You receives funding from the University of Texas MD Anderson Cancer Center G. S. Hogan Gastrointestinal Cancer Research Fund. Ms Guiffre, Dr Mendoza Silveiras, Mr Spiegel, and Ms Greenamyer are employees of the Colon Cancer Alliance, and Ms Wade serves as a consultant to the Colon Cancer Alliance. Dr Sifri and Ms Axilbund have no conflicts of interest to disclose.