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Treatment of Blepharospasm With Botulinum Toxin

      Many therapeutic modalities, including medications, excision of the muscles used in closure of the eyelids (myectomy), and selective extirpation of branches of the facial nerve (neurectomy), have been used for the management of blepharospasm. Because of limited effectiveness and undesirable side effects, none of these treatments has been completely satisfactory. Recent reports about injection of botulinum toxin indicate that it is safe and effective for most patients. Relief from blepharospasm, however, is usually transient, and repeated injections are usually necessary. The current availability of effective therapy for blepharospasm emphasizes the importance of prompt diagnosis and referral of affected patients to physicians knowledgeable in the use of botulinum toxin and other therapeutic approaches.
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      REFERENCES

        • Henderson JW
        Essential blepharospasm.
        Trans Am Ophthalmol Soc. 1956; 54: 453-520
        • Paulson GW
        Meige's syndrome: dyskinesia of the eyelids and facial muscles.
        Geriatrics. August 1972; 27: 69-73
        • Marsden CD
        Blepharospasm-oromandibular dystonia syndrome (Brueghel's syndrome): a variant of adult-onset torsion dystonia?.
        J Neurol Neurosurg Psychiatry. 1976; 39: 1204-1209
        • Jankovic J
        • Havins WE
        • Wilkins RB
        Blinking and blepharospasm: mechanism, diagnosis, and management.
        JAMA. 1982; 248: 3160-3164
        • Rotberg MH
        Biofeedback for ophthalmologic disorders.
        Surv Ophthalmol. 1983; 27: 381-386
        • Kao I
        • Drachman DB
        • Price DL
        Botulinum toxin: mechanism of presynaptic blockade.
        Science. 1976; 193: 1256-1258
        • Scott AB
        Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery.
        Ophthalmology. 1980; 87: 1044-1049
        • Scott AB
        • Kennedy RA
        • Stubbs HA
        Botulinum A toxin injection as a treatment for blepharospasm.
        Arch Ophthalmol. 1985; 103: 347-350
        • Waller RR
        • Kennedy RH
        • Henderson JW
        • Kesty KR
        Management of blepharospasm.
        Trans Am Ophthalmol Soc. 1985; 83: 367-385
        • Frueh BR
        • Felt DP
        • Wojno TH
        • Musch DC
        Treatment of blepharospasm with botulinum toxin: a preliminary report.
        Arch Ophthalmol. 1984; 102: 1464-1468
        • Tsoy EA
        • Buckley EG
        • Dutton JJ
        Treatment of blepharospasm with botulinum toxin.
        Am J Ophthalmol. 1985; 99: 176-179
        • Frueh BR
        • Musch DC
        Treatment of facial spasm with botulinum toxin: an interim report.
        Ophthalmology. 1986; 93: 917-923
        • Cohen DA
        • Savino PJ
        • Stern MB
        • Hurtig HI
        Botulinum injection therapy for blepharospasm: a review and report of 75 patients.
        Clin Neuropharmacol. 1986; 9: 415-429
        • Engstrom PF
        • Arnoult JB
        • Mazow ML
        • Prager TC
        • Wilkins RB
        • Byrd WA
        • Hofmann RJ
        Effectiveness of botulinum toxin therapy for essential blepharospasm.
        Ophthalmology. 1987; 94: 971-975
        • Dutton JJ
        • Buckley EG
        Botulinum toxin in the management of blepharospasm.
        Arch Neurol. 1986; 43: 380-382
        • Mauriello Jr, JA
        • Coniaris H
        • Haupt EJ
        Use of botulinum toxin in the treatment of one hundred patients with facial dyskinesias.
        Ophthalmology. 1987; 94: 976-979
        • Flynn JT
        • Bachynski B
        Botulinum toxin therapy for strabismus and blepharospasm: Bascom Palmer Eye Institute experience. In Pediatric Ophthalmology and Strabismus (Transactions of the New Orleans Academy of Ophthalmology). Raven Press, New York1986: 73-88
        • Perman KI
        • Baylis HI
        • Rosenbaum AL
        • Kirschen DG
        The use of botulinum toxin in the medical management of benign essential blepharospasm.
        Ophthalmology. 1986; 93: 1-3
        • Shore JW
        • Leone Jr, CR
        • O'Connor PS
        • Neuhaus RW
        • Arnold AC
        Botulinum toxin for the treatment of essential blepharospasm.
        Ophthalmic Surg. 1986; 17: 747-753
        • Greene P
        • Shale H
        • Fahn S
        • Brin M
        • Friedman A
        Treatment of torticollis with injections of botulinum toxin (abstract).
        Neurology. 1987; 37: 123
        • Gonnering RS
        Negative antibody response to long-term treatment of facial spasm with botulinum toxin.
        Am J Ophthalmol. 1988; 105: 313-315
        • Gillum WN
        • Anderson RL
        Blepharospasm surgery: an anatomical approach.
        Arch Ophthalmol. 1981; 99: 1056-1062
        • McCord Jr, CD
        • Coles WH
        • Shore JW
        • Spector R
        • Putnam JR
        Treatment of essential blepharospasm. I. Comparison of facial nerve avulsion and eyebrow-eyelid muscle stripping procedure.
        Arch Ophthalmol. 1984; 102: 266-268
        • Jones Jr, TW
        • Waller RR
        • Samples JR
        Myectomy for essential blepharospasm.
        Mayo Clin Proc. 1985; 60: 663-666