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Cutaneous Malignant Melanoma in Rochester, Minnesota: Trends in Incidence and Survivorship, 1950 Through 1985

      In Rochester, Minnesota, 107 incidence cases of cutaneous malignant melanoma (in 46 male and 61 female patients) were diagnosed during the years 1950 through 1985. Overall crude incidence rates were 6.0 and 6.6 per 100,000 males and females, respectively. Evaluation of trends in 9-year periods showed that the rates increased from 3.2 to 8.9 for males ( P = 0.015) and from 4.4 to 11.7 for females ( P<0.001). Age-specific rates suggested that the highest incidence occurs in the age-groups 50 to 59 years and 70 years or older for males and 40 to 49 years and 70 years or older for females. Lesions were most common in the head and neck area among males ( P = 0.044) and on the lower extremities among females ( P = 0.018). The most frequent histologic type was superficial spreading melanoma (61%). Five-year survival was diminished overall for patients with cutaneous malignant melanoma—0.72 in comparison with 0.88 expected for the general population. Statistically significant risk factors for survival were depth of invasion of the lesion (Clark level), thickness of the lesion, histologic type, and age of the patient.
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      REFERENCES

        • National Cancer Institute
        1986 Annual Cancer Statistics Review. Publication No. NIH 87–2789. US Government Printing Office, Washington, DC1987: II.B.2 (II.B.4; IV.B.26)
        • National Cancer Institute
        SEER Program: Cancer Incidence and Mortality in the U.S. 1973–81. Publication No. NIH 85–1837. US Government Printing Office, Washington, DC1984
        • Green A
        Incidence and reporting of cutaneous melanoma in Queensland.
        Australas J Dermatol. 1982; 23: 105-109
        • Lee JAH
        Melanoma.
        in: Schottenfeld D Fraumeni Jr., JF Cancer Epidemiology and Prevention. WB Saunders Company, Philadelphia1982: 984-995
        • Schreiber MM
        • Bozzo PD
        • Moon TE
        Malignant melanoma in southern Arizona.
        Arch Dermatol. 1981; 117: 6-11
        • Philipp R
        • Hastings A
        • Briggs J
        • Sizer J
        Are malignant melanoma time trends explained by changes in histopathological criteria for classifying pigmented skin lesions?.
        J Epidemiol Community Health. 1987; 42: 14-16
        • Hinds MW
        • Kolonel LN
        Malignant melanoma of the skin in Hawaii, 1960–1977.
        Cancer. 1980; 45: 811-817
        • Østerlind A
        • Jensen OM
        Trends in incidence of malignant melanoma of the skin in Denmark 1943–1982.
        Recent Results Cancer Res. 1986; 102: 8-17
        • Hu J
        Incidence and mortality of malignant melanoma in Ontario, 1964–1975.
        Can J Public Health. 1985; 76: 347-351
        • Swerdlow AJ
        Incidence of malignant melanoma of the skin in England and Wales and its relationship to sunshine.
        Br Med J. 1979; 2: 1324-1327
        • Glass AG
        • Hoover RN
        The emerging epidemic of melanoma and squamous cell skin cancer.
        JAMA. 1989; 262: 2097-2100
        • Resseguie LJ
        • Marks SJ
        • Winkelmann RK
        • Kurland LT
        Malignant melanoma in the resident population of Rochester, Minnesota.
        Mayo Clin Proc. 1977; 52: 191-195
        • Kurland LT
        • Molgaard CA
        The patient record in epidemiology.
        Sci Am. October 1981; 245: 54-63
        • Armitage P
        Tests for linear trends in proportions and frequencies.
        Biometrics. 1955; 11: 375-386
        • Cox DR
        Regression models and life-tables (with discussion).
        J R Stat Soc [B]. 1972; 34: 187-220
        • Jensen OM
        • Bolander AM
        Trends in malignant melanoma of the skin.
        World Health Stat Q. 1980; 33: 2-26
        • Magnus K
        Incidence of malignant melanoma of the skin in the five Nordic countries: significance of solar radiation.
        Int J Cancer. 1977; 20: 477-485
        • Hakulinen T
        • Andersen A
        • Malker B
        • Pukkala E
        • Schou G
        • Tulinius H
        Trends in cancer incidence in the Nordic countries: a collaborative study of the five Nordic Cancer Registries.
        Acta Pathol Microbiol Immunol Scand Suppl. 1986; 288: 1-151
      1. Utah Cancer Registry: Malignant melanoma (skin). Utah Cancer Rep 2 (No. 2), Spring 1987

        • English DR
        • Heenan PJ
        • Holman CDJ
        • Armstrong BK
        • Blackwell JB
        • Kelsall GRH
        • Matz LR
        • Singh A
        • ten Seldam REJ
        Melanoma in Western Australia 1975–76 to 1980–81: trends in demographic and pathological characteristics.
        Int J Cancer. 1986; 37: 209-215
        • Van der Esch EP
        • Stukonis MK
        Contrasting incidences along with descriptive markers in the epidemiology of melanoma.
        Pathology. 1985; 17: 313-320
        • Bos MY
        • Deane M
        A retrospective study of 275 cases of cutaneous malignant melanoma in the East Midland region.
        Br J Plast Surg. 1982; 35: 60-62
        • McLeod GR
        • Davis NC
        • Little JH
        • Green A
        • Chant D
        Melanoma in Queensland, Australia: experience of the Queensland Melanoma Project.
        in: Balch CM Milton GW Cutaneous Melanoma: Clinical Management and Treatment Results Worldwide. JB Lippincott Company, Philadelphia1985: 379-387
        • MacKie RM
        • Hunter JAA
        Cutaneous malignant melanoma in Scotland.
        Br J Cancer. 1982; 46: 75-80
        • Crombie IK
        Distribution of malignant melanoma on the body surface.
        Br J Cancer. 1981; 43: 842-849
        • Teppo L
        • Pakkanen M
        • Hakulinen T
        Sunlight as a risk factor of malignant melanoma of the skin.
        Cancer. 1978; 41: 2018-2027
        • Holman CDJ
        • Mulroney CD
        • Armstrong BK
        Epidemiology of pre-invasive and invasive malignant melanoma in Western Australia.
        Int J Cancer. 1980; 25: 317-323
        • McCarthy WH
        • Shaw HM
        • Milton GW
        • McGovern VJ
        Melanoma in New South Wales, Australia: experience at the Sydney Melanoma Unit.
        in: Balch CM Milton GW Cutaneous Melanoma: Clinical Management and Treatment Results Worldwide. JB Lippincott Company, Philadelphia1985: 371-378
        • Bonett A
        • Roder D
        • Esterman A
        Melanoma case survival rates in South Australia by histological type, thickness and level of tumour at diagnosis.
        Med J Aust. 1986; 144: 680-682