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Disseminated Aspergillus terreus Infection in Immunocompromised Hosts

      Aspergillus terreus is ubiquitous in the environment but has rarely been found to be pathogenic. When recovered from clinical specimens, it is commonly considered a saprophyte. We report two cases of fatal disseminated A. terreus infection. The first patient was receiving corticosteroid therapy for immune thrombocytopenia when the condition developed, and the second patient was receiving immunosuppressive therapy after bone marrow transplantation for myelodysplasia. We also describe the frequency of recovery of A. terreus in our laboratory. The serious pathogenic potential of A. terreus in immunocompromised hosts should be recognized.
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        • Chang S-W
        • King TE
        Aspergillus terreus causing invasive pulmonary aspergillosis with air-crescent sign.
        J Natl Med Assoc. 1986; 78 (248): 251-253
        • Tracy SL
        • McGinnis MR
        • Peacock Jr, JE
        • Cohen MS
        • Walker DH
        Disseminated infection by Aspergillus terreus.
        Am J Clin Pathol. 1983; 80: 728-733
        • Moore CK
        • Hellreich MA
        • Coblentz CL
        • Roggli VL
        Aspergillus terreus as a cause of invasive pulmonary aspergillosis.
        Chest. 1988; 94: 889-891
        • Kabay MJ
        • Robinson WF
        • Huxtable CRR
        • McAleer R
        The pathology of disseminated Aspergillus terreus infection in dogs.
        Vet Pathol. 1985; 22: 540-547
        • Onsberg P
        • Stahl D
        • Veien NK
        Onychomycosis caused by Aspergillus terreus.
        Sabouraudia. 1978; 16: 39-46
        • Suseelan AV
        • Gugnani HC
        • Ojukwu JO
        Primary cutaneous aspergillosis due to Aspergillus terreus (letter to the editor).
        Arch Dermatol. 1976; 112: 1468
        • Gregson AEW
        • La Touche CJ
        The significance of mycotic infection in the aetiology of otitis externa.
        J Laryngol Otol. 1961; 75: 167-170
        • English MP
        • Dalton GA
        An outbreak of fungal infections of post-operative aural cavities.
        J Laryngol Otol. 1962; 76: 1-11
        • Powell DEB
        • English MP
        • Duncan EHL
        Clinical, bacteriological and mycological findings in post-operative ear cavities.
        J Laryngol Otol. 1962; 76: 12-21
        • English MP
        Preliminary observations on some Aspergillus species in relation to their ro1e as pathogens of aural cavities.
        J Laryngol Otol. 1963; 77: 422-429
        • Cheetham HD
        Subcutaneous infection due to Aspergillus terreus.
        J Clin Pathol. 1964; 17: 251-253
        • Agarwal LP
        • Malik SRK
        • Mohan M
        • Mahopatra LN
        Orbital aspergillosis.
        Br J Ophthalmol. 1962; 46: 559-562
        • Mahgoub ES
        • Ismail SA
        • El Hassan AM
        Cervical lymphadenopathy caused by Aspergillus terreus.
        Br Med J. 1969; 1: 689-690
        • Seligsohn R
        • Rippon JW
        • Lerner SA
        Aspergillus terreus osteomyelitis.
        Arch Intern Med. 1977; 137: 918-920
        • Glotzbach RE
        Aspergillus terreus infection of pseudoaneurysm of aortofemoral vascular graft with contiguous vertebral osteomyelitis.
        Am J Clin Pathol. 1982; 77: 224-227
        • Stein SC
        • Corrado ML
        • Friedlander M
        • Farmer P
        Chronic mycotic meningitis with spinal involvement (arachnoiditis): a report of five cases.
        Ann Neurol. 1982; 11: 519-524
        • Rippon JW
        • Anderson DN
        • Soo Hoo M
        Aspergillosis: comparative virulence, metabolic rate, growth rate and ubiquinone content of soil and human isolates of Aspergillus terreus.
        Sabouraudia. 1974; 12: 157-161
        • Drexler L
        • Rytel M
        • Keelan M
        • Bonchek LI
        • Olinger GN
        Aspergillus terreus infective endocarditis on a porcine heterograft valve.
        J Thorac Cardiovasc Surg. 1980; 79: 269-274
        • Mershon JC
        • Samuelson DR
        • Layman TE
        Left ventricular “fibrous body” aneurysm caused by Aspergillus endocarditis.
        Am J Cardiol. 1968; 22: 281-285
        • Laham MN
        • Carpenter JL
        Aspergillus terreus, a pathogen capable of causing infective endocarditis, pulmonary mycetoma, and allergic bronchopulmonary aspergillosis.
        Am Rev Respir Dis. 1982; 125: 769-772
        • Laham MN
        • Allen RC
        • Greene JC
        Allergic bronchopulmonary aspergillosis (ABPA) caused by Aspergillus terreus: specific lymphocyte sensitization and antigen-directed serum opsonic activity.
        Ann Allergy. 1981; 46: 74-80
        • Vincken W
        • Schandevijl W
        • Roels P
        Allergic bronchopulmonary aspergillosis caused by Aspergillus terreus (letter to the editor).
        Am Rev Respir Dis. 1983; 127: 388-389
        • Kennedy WPU
        • Milne LJR
        • Blyth W
        • Crompton GK
        Two unusual organisms, Aspergillus terreus and Metschni-kowia pulcherrima, associated with the lung disease of ankylosing spondylitis.
        Thorax. 1972; 27: 604-610
        • Gerson SL
        • Talbot GH
        • Hurwitz S
        • Strom BL
        • Lusk EJ
        • Cassileth PA
        Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia.
        Ann Intern Med. 1984; 100: 345-351
        • Aisner J
        • Murillo J
        • Schimpff SC
        • Steere AC
        Invasive aspergillosis in acute leukemia: correlation with nose cultures and antibiotic use.
        Ann Intern Med. 1979; 90: 4-9
        • Weiner MH
        Antigenemia detected by radioimmunoassay in systemic aspergillosis.
        Ann Intern Med. 1980; 92: 793-796
        • Zimmerman LE
        Fatal fungus infections complicating other diseases.
        Am J Clin Pathol. 1955; 25: 46-65
        • Walsh TJ
        • Bulkley BH
        Aspergillus pericarditis: clinical and pathologic features in the immunocompromised patient.
        Cancer. 1982; 49: 48-54
        • Aisner J
        • Schimpff SC
        • Wiernik PH
        Treatment of invasive aspergillosis: relation of early diagnosis and treatment to response.
        Ann Intern Med. 1977; 86: 539-543
        • Fisher BD
        • Armstrong D
        • Yu B
        • Gold JWM
        Invasive aspergillosis: progress in early diagnosis and treatment.
        Am J Med. 1981; 71: 571-577