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Therapeutic Drug Monitoring of Cyclosporine

      Cyclosporine (Sandimmune, formerly cyclosporin A) is a unique cyclic polypeptide that has been shown to be very successful in prolonging graft survival in human liver, heart, and kidney transplantation. Cyclosporine is an 11-amino acid cyclic peptide that contains primarily hydrophobic amino acids and one unique hydroxylated, unsaturated amino acid, “C-9 ene.” Although the mechanism of action of cyclosporine is unclear, it is now believed to interfere with the secretion or action of interleukin-2 (II-2), a monokine that is a growth factor for T-lymphocytes.
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