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Fluoxetine Abuse


      In this report, we describe the abuse of fluoxetine (an antidepressant) in two patients who had histories of substance abuse.

      Material and Methods

      Specific details of the stimulant effects of fluoxetine, used in excessive dosages and in conjunction with other drugs, are discussed.


      After hospitalization, our two patients were able to discontinue use of fluoxetine and had improved mentation.


      Although the mechanism for this phenomenon is unknown, we postulate that drug craving and behavioral factors are involved.
      DSM-III-R ( revised third edition of the Diagnostic and Statistical Manual of Mental Disorders), LSD ( lysergic acid diethylamide)
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