Abstract
Objective
To examine the association between accelerometer-derived sedentary and physical activity
and prostate-specific antigen (PSA) in a nationally representative sample of men in
the United States.
Participants and Methods
Data from the 2003-2004 and 2005-2006 National Health and Nutrition Examination Survey
cycles were used in the present study, with data from 1672 adult male participants
used in the analyses. The manuscript was prepared between July 7, 2012, and September
26, 2012. Sedentary and physical activity was objectively measured using an accelerometer.
Covariates included various demographic, dietary, biological, and immunologic variables
including age, height, weight, body mass index, race/ethnicity, marital status, education,
and poverty-income ratio; dietary fiber, fat, protein, and carbohydrate intake and
total energy intake; vitamin C and vitamin E; alcohol intake; medication use; concentrations
of cotinine, total cholesterol, and high-density lipoprotein cholesterol; blood pressure
(elevated or not elevated); diabetes; C-reactive protein; and white blood cell count
and number of basophils and eosinophils.
Results
Only after controlling for all covariates, for every 1-hour increase in sedentary
behavior, participants were 16% more likely to have an elevated PSA concentration
(odds ratio, 1.16 [95% CI, 1.06-1.27]; P=.001). For every 1-hour increase in light physical activity, participants were 18%
less likely to have an elevated PSA concentration (odds ratio, 0.82 [95% CI, 0.68-1.00];
P=.05).
Conclusion
Individuals who engage in more sedentary behavior and lower levels of light physical
activity have higher PSA concentrations. Future studies are needed to better identify
the potential underlying mechanisms delineating the association between sedentary
and physical activity and PSA concentration.
Abbreviations and Acronyms:
BMI (body mass index), CRP (C-reactive protein), HDL (high-density lipoprotein), NHANES (National Health and Nutrition Examination Survey), PSA (prostate-specific antigen)To read this article in full you will need to make a payment
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Article Info
Footnotes
See editorial comment, page 1
Identification
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