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George R. Minot—Nobel Prize for the Treatment of Pernicious Anemia

      George R. Minot was born in Boston, Mass, on December 2, 1885. He was a great-grandson of Dr James Jackson (1777-1867), cofounder of the Massachusetts General Hospital in 1821. His father was a private practitioner and taught at Harvard Medical School. Minot attended private schools in Boston and graduated from Harvard College in 1908. He enrolled at Harvard Medical School, and during his junior year, he demonstrated that a patient considered to have pernicious anemia actually had congenital hemolytic anemia. After graduation in 1912, Minot became a “house pupil” (intern) at the Massachusetts General Hospital. He became interested in diseases of the blood and began taking meticulous histories of the dietary habits of patients with anemia. He was a resident at the Johns Hopkins University and worked in the laboratory of William H. Howell (1860-1945), who was interested in the coagulation of blood and had identified heparin. As a resident, Minot determined that delayed coagulation in patients with jaundice who had bleeding tendencies was due to a decreased level of prothrombin.
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