INDIGENOUS GUT MICROBIOTA
Identification

Phyla | Representative genera |
---|---|
Bacteria | |
Firmicutes | Ruminococcus |
Clostridium | |
Peptostreptococcus | |
Lactobacillus | |
Enterococcus | |
Bacteroidetes | Bacteroides |
Proteobacteria | Desulfovibrio |
Escherichia | |
Helicobacter | |
Verrucomicrobia | |
Actinobacteria | Bifidobacterium |
Cyanobacteria | |
Synergistes | |
Archaea | |
Euryarchaeota | Methanobrevibacter |
Development

Metabolic Functions
MICROBIAL CONTRIBUTIONS TO OBESITY
Dietary Energy Extraction
Chronic Systemic Inflammation

Gut Microbiota Composition in Obese vs Lean Mice
Gut Microbiota Composition in Obese vs Lean Humans
Energy Homeostasis
MODIFYING THE ECOSYSTEM AS A THERAPEUTIC STRATEGY
Antibiotics
Prebiotics
Probiotics
FUTURE DIRECTIONS
Besselink MG, van Santvoort HC, Buskens E, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial [published online ahead of print February 13, 2008]. Lancet, doi:10.1016/S0140-6736(08)60207-X.
CONCLUSION
ADDENDUM
REFERENCES
- Extreme obesity: a new medical crisis in the United States.Mayo Clin Proc. 2006; 81: S5-S10
- The epidemiology of obesity.Gastroenterology. 2007; 132: 2087-2102
- To eat or not to eat—how the gut talks to the brain.N Engl J Med. 2003; 349: 926-928
- Gut peptides and the regulation of appetite.Obes Rev. 2006; 7: 163-182
- Gut peptides in the regulation of food intake and energy homeostasis.Endocr Rev. 2006 Dec; 27 (Epub 2006 Oct 31.): 719-727
- Integrated upper gastrointestinal response to food intake.Gastroenterology. 2006; 131: 640-658
- Understanding and addressing the epidemic of obesity: an energy balance perspective.Endocr Rev. 2006 Dec; 27 (Epub 2006 Nov 22.): 750-761
- Obesity and the environment: where do we go from here?.Science. 2003; 299: 853-855
- Appetite and the regulation of body composition.FASEB J. 1994; 8: 302-310
- Central nervous system control of food intake and body weight.Nature. 2006; 443: 289-295
- Metagenomic analysis of the human distal gut microbiome.Science. 2006; 312: 1355-1359
- Development of the human infant intestinal microbiota [published online ahead of print June 26, 2007].PLoS Biol. 2007; 5: e177https://doi.org/10.1371/journal.pbio.0050177
- Diversity of the human intestinal microbial flora.Science. 2005 Jun 10; 308 (Epub 2005 Apr 14.): 1635-1638
- Bacterial diversity in the human gut.Adv Appl Microbiol. 2004; 54: 261-289
- Gastrointestinal microbiology enters the metagenomics era.Curr Opin Gastroenterol. 2008; 24: 4-10
- Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity.J Bacteriol. 1998; 180: 4765-4774
- Phylogenetic identification and insitu detection of individual microbial cells without cultivation.Microbiol Rev. 1995; 59: 143-169
- Obesity alters gut microbial ecology.Proc Natl Acad Sci U S A. 2005 Aug 2; 102 (Epub 2005 Jul 20.): 11070-11075
- Molecular-phlyogenetic characterization of microbial community imbalances in human inflammatory bowel disease.Proc Natl Acad Sci U S A. 2007 Aug 21; 104 (Epub 2007 Aug 15.): 13780-13785
- Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream.Exp Hematol. 2002; 30: 503-512
- The indigenous gastrointestinal microflora.Trends Microbiol. 1996; 4: 430-435
- Developmental microbial ecology of the neonatal gastrointestinal tract.Am J Clin Nutr. 1999; 69: 1035S-1045S
- Intestinal microflora.Gastroenterology. 1971; 60: 1110-1129
- Microbial ecology: human gut microbes associated with obesity.Nature. 2006; 444: 1022-1023
- The role of the intestinal microflora for the development of the immune system in early childhood.Eur J Nutr. 2002; 41: 132-137
- The host genotype affects the bacterial community in the human gastrointestinal tract.Microb Ecol Health Dis. 2001; 13: 129-134
- Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles.Gut. 2001; 48: 198-205
- Interactions among microorganisms of the indigenous intestinal flora and their influence on the host.Rev Infect Dis. 1984 Mar-Apr; 6: S73-S79
- Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology.Microbiol Mol Biol Rev. 1998; 62: 1157-1170
- Microbes and the developing gastrointestinal tract.Nutr Clin Pract. 2007; 22: 174-182
- Human colonic microbiota: ecology, physiology and metabolic potential of intestinal bacteria.Scand J Gastroenterol Suppl. 1997; 222: 3-9
- Effect of the normal microbial flora on gastrointestinal motility.Proc Soc Exp Biol Med. 1967; 126: 301-304
- Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells.Proc Natl Acad Sci U S A. 2002 Nov 26; 99 (Epub 2002 Nov 13.): 15451-15455
- Hostbacterial mutualism in the human intestine.Science. 2005; 307: 1915-1920
- Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora.Gut. 1989; 30: 971-979
- How host-microbial interactions shape the nutrient environment of the mammalian intestine.Annu Rev Nutr. 2002; 22 (Epub 2002 Apr 4.): 283-307
- Colonic microflora: nutrition and health: summary and conclusions of an International Life Sciences Institute (ILSI) [Europe] workshop held in Barcelona, Spain.Nutr Rev. 1995; 53: 127-130
- Enteric microbial flora, bacterial overgrowth and short bowel syndrome.Clin Gastroenterol Hepatol. 2006; 4: 11-20
- Probiotics and gastrointestinal health.Am J Gastroenterol. 2000; 95: S2-S4
- The gut microbiota as an environmental factor that regulates fat storage.Proc Natl Acad Sci U S A. 2004 Nov 2; 101 (Epub 2004 Oct 25.): 15718-15723
- Mechanisms underlying the resistance to diet-induced obesity in germ-free mice.Proc Natl Acad Sci U S A. 2007 Jan 16; 104 (Epub 2007 Jan 8.): 979-984
- An obesity-associated gut microbiome with increased capacity for energy harvest.Nature. 2006; 444: 1027-1031
- Inflammation, stress and diabetes.J Clin Invest. 2005; 115: 1111-1119
- Metabolic endotoxemia initiates obesity and insulin resistance.Diabetes. 2007 Jul; 56 (Epub 2007 Apr 24.): 1761-1772
- CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.Science. 1990; 249: 1431-1433
- Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat.J Surg Res. 1991; 51: 106-112
- Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes.Am J Physiol Endocrinol Metab. 2007 Mar; 292 (Epub 2006 Nov 7.): E740-E747
- Effect of monensin and lasalocid-sodium on the growth of methanogenic and rumen saccharolytic bacteria.Appl Environ Microbiol. 1979; 38: 72-77
- A humanized gnotobiotic mouse model of hostarchaeal-bacterial mutualism.Proc Natl Acad Sci U S A. 2006 Jun 27; 103 (Epub 2006 Jun 16.): 10011-10016
- Bacteroides thetaiotamicron: a dynamic, niche-adapted human symbiont.Bioessays. 2003; 25: 926-929
- Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut.Proc Natl Acad Sci U S A. 2007 Jun 19; 104 (Epub 2007 Jun 11.): 10643-10648
- Antibiotic treatment partially protects against type 1 diabetes in the bio-breeding diabetes-prone rat: is the gut flora involved in the development of type 1 diabetes?.Diabetologia. 2006 Sep; 49 (Epub 2006 Jul 1.): 2105-2108
- Functional foods: concepts and application to inulin and oligofructose.Br J Nutr. 2002; 87: S139-S143
- Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin.Gastroenterology. 1995; 108: 975-982
- Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide and ghrelin) in rats.Br J Nutr. 2004; 92: 521-526
- Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1.Obes Res. 2005; 13: 1000-1007
- Impact of inulin and oligofructose on gastrointestinal peptides.Br J Nutr. 2005; 93: S157-S161
- Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora.Br J Nutr. 2001; 86: 291-300
- Effect of fat replacement by inulin or lupin-kernel fibre on sausage patty acceptability, post-meal perceptions of satiety and food intake in men.Br J Nutr. 2004; 91: 591-599
- Oligofructose promotes satiety in healthy humans: a pilot study.Eur J Clin Nutr. 2006; 60: 567-572
- Selective increases of bifido-bacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia.Diabetologia. 2007 Nov; 50 (Epub 2007 Sep 6.): 2374-2383
- Probiotics, prebiotics, and synbiotics—approaching a definition.Am J Clin Nutr. 2001; 73: 361S-364S
- Use of probiotics in humans: an analysis of the literature.Gastroenterol Clin North Am. 2005; 34: 547-570
- Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice.Biochim Biophys Acta. 2006 Jul; 1761 (Epub 2006 May 20.): 736-744
- Effect of conjugated linoleic acid on body composition in mice.Lipids. 1997; 32: 853-858
- Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain.Am J Clin Nutr. 2006; 83: 606-612
- Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host.PLoS Biol. 2006; 4: e413https://doi.org/10.1371/journal.pbio.0040413
- Probiotic modulation of symbiotic gut microbial-host metabolic interaction in a humanized microbiome mouse model.Mol Syst Biol. 2008; 4: 157https://doi.org/10.1038/msb4100190
Besselink MG, van Santvoort HC, Buskens E, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial [published online ahead of print February 13, 2008]. Lancet, doi:10.1016/S0140-6736(08)60207-X.
- Executive summary: scientific and regulatory challenges of development of probiotics as foods and drugs.Clin Infect Dis. 2008; 46: S53-S57
- Early differences in fecal microbiota composition in children may predict overweight.Am J Clin Nutr. 2008; 87: 534-538