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SYMPOSIUM ON CARDIOVASCULAR DISEASES| Volume 84, ISSUE 5, P465-481, May 2009

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Acute Aortic Syndromes and Thoracic Aortic Aneurysm

  • Vijay S. Ramanath
    Correspondence
    Address correspondence to Vijay S. Ramanath, MD, Section of Cardiology, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, One Medical Center Dr, Lebanon, NH 03756-0001. Individual reprints of this article and a bound reprint of the entire Symposium on Cardiovascular Diseases will be available for purchase from our Web site www.mayoclinicproceedings.com
    Affiliations
    Section of Cardiology, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Lebanon, NH, Mayo Clinic, Rochester, MN
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  • Jae K. Oh
    Affiliations
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
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  • Author Footnotes
    1 Dr Sundt receives grants for clinical or laboratory research support from Atricure, Boehringer Ingelheim, Bolton Medical, Edwards Lifesciences, Jarvik Heart, Sorin Group/Carbomedics, St Jude Medical, Thoratec Corporation, Ventracor, and W. L. Gore and Associates. The Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, also holds technology licensing agreements with St Jude Medical and the Sorin Group. Dr Eagle received grant/research support from Biosite, Bristol-Myers Squibb, Blue Cross Blue Shield of Michigan, the Hewlett Foundation, the Mardigian Fund, Pfizer, sanofiaventis, and the Varbedian Fund. Dr Eagle is also a consultant for the National Institutes of Health National Heart, Lung, and Blood Institute; Pfizer; sanofiaventis; the Robert Wood Johnson Foundation; and Affinia.
    Thoralf M. Sundt III
    Footnotes
    1 Dr Sundt receives grants for clinical or laboratory research support from Atricure, Boehringer Ingelheim, Bolton Medical, Edwards Lifesciences, Jarvik Heart, Sorin Group/Carbomedics, St Jude Medical, Thoratec Corporation, Ventracor, and W. L. Gore and Associates. The Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, also holds technology licensing agreements with St Jude Medical and the Sorin Group. Dr Eagle received grant/research support from Biosite, Bristol-Myers Squibb, Blue Cross Blue Shield of Michigan, the Hewlett Foundation, the Mardigian Fund, Pfizer, sanofiaventis, and the Varbedian Fund. Dr Eagle is also a consultant for the National Institutes of Health National Heart, Lung, and Blood Institute; Pfizer; sanofiaventis; the Robert Wood Johnson Foundation; and Affinia.
    Affiliations
    Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN
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  • Kim A. Eagle
    Affiliations
    University of Michigan Cardiovascular Center, Ann Arbor
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  • Author Footnotes
    1 Dr Sundt receives grants for clinical or laboratory research support from Atricure, Boehringer Ingelheim, Bolton Medical, Edwards Lifesciences, Jarvik Heart, Sorin Group/Carbomedics, St Jude Medical, Thoratec Corporation, Ventracor, and W. L. Gore and Associates. The Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, also holds technology licensing agreements with St Jude Medical and the Sorin Group. Dr Eagle received grant/research support from Biosite, Bristol-Myers Squibb, Blue Cross Blue Shield of Michigan, the Hewlett Foundation, the Mardigian Fund, Pfizer, sanofiaventis, and the Varbedian Fund. Dr Eagle is also a consultant for the National Institutes of Health National Heart, Lung, and Blood Institute; Pfizer; sanofiaventis; the Robert Wood Johnson Foundation; and Affinia.
      Acute and chronic aortic diseases have been diagnosed and studied by physicians for centuries. Both the diagnosis and treatment of aortic diseases have been steadily improving over time, largely because of increased physician awareness and improvements in diagnostic modalities. This comprehensive review discusses the pathophysiology and risk factors, classification schemes, epidemiology, clinical presentations, diagnostic modalities, management options, and outcomes of various aortic conditions, including acute aortic dissection (and its variants intramural hematoma and penetrating aortic ulcers) and thoracic aortic aneurysms. Literature searches of the PubMed database were conducted using the following keywords: aortic dissection, intramural hematoma, aortic ulcer, and thoracic aortic aneurysm. Retrospective and prospective studies performed within the past 20 years were included in the review; however, most data are from the past 15 years.
      AAD (acute aortic dissection), ACS (acute coronary syndrome), ARB (angiotensin II receptor blocker), COPD (chronic obstructive pulmonary disease), CT (computed tomography), dP/dt (force of left ventricular ejection), EDS (Ehlers-Danlos syndrome), FBN (fibrillin), ICU (intensive care unit), IMH (intramural hematoma), IRAD (International Registry of Acute Aortic Dissection), MRI (magnetic resonance imaging), TAA (thoracic aortic aneurysm), TEE (transesophageal echocardiography), TGFBR (transforming growth factor β receptor)
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