Abstract
Objective
To examine the association between computer use, physical exercise, aging, and mild
cognitive impairment (MCI).
Patients and Methods
The Mayo Clinic Study of Aging is a population-based study of aging and MCI in Olmsted
County, Minnesota. The study sample consists of a random sample of 926 nondemented
individuals aged 70 to 93 years who completed self-reported questionnaires on physical
exercise, computer use, and caloric intake within 1 year of the date of interview.
The study was conducted from April 1, 2006, through November 30, 2008. An expert consensus
panel classified each study participant as cognitively normal or having MCI on the
basis of published criteria.
Results
Using a multivariable logistic regression model, we examined the impact of the presence
during the study period of 2 lifestyle factors (physical exercise and computer use)
after adjusting for a third lifestyle factor (caloric intake) on aging and MCI. We
also adjusted for age, sex, education, medical comorbidity, and depression. The median
daily caloric intake was significantly higher in participants with MCI than in controls
(odds ratio, 1.04; 95% confidence interval, 1.02-1.06; P=.001). Participants who engaged in both moderate physical exercise and computer use
had significantly decreased odds of having MCI (odds ratio [95% confidence interval],
0.36 [0.20-0.68]) compared with the reference group. In the interaction analyses,
there was an additive interaction (P=.012) but not multiplicative interaction (P=.780).
Conclusion
In this population-based sample, the presence of both physical exercise and computer
use as assessed via survey was associated with decreased odds of having MCI, after
adjustment for caloric intake and traditional confounders.
Abbreviations and Acronyms:
CDR (Clinical Dementia Rating), CI (confidence interval), MCI (mild cognitive impairment), OR (odds ratio)To read this article in full you will need to make a payment
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Article info
Footnotes
Grant Support: This study was supported by grants from the National Institutes of Health (K01 MH068351, RR024150, U01 AG006786, K01 AG028573, P50 AG016574, R01 AR030582, and R01 NS033978), by the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program, by the RWJ Foundation (Harold Amos) Medical Faculty Development Program, and by the European Union Regional Development Fund (Project FNUSA-ICRC: CZ.1.05/1.1.00/02.0123).
Potential Competing Interests: Dr Knopman serves as deputy editor for Neurology, serves on a Data Safety Monitoring Board for Lilly Pharmaceuticals, is an investigator in clinical trials sponsored by Baxter, Elan Pharmaceuticals, and Forest Pharmaceuticals, and receives research support from the National Institutes of Health. Dr Boeve receives publishing royalties for Behavioral Neurology of Dementia (Cambridge Medicine, 2009), and receives research support from Cephalon, Inc., and Allon Pharmaceuticals. Dr Petersen is the chair of the Data Monitoring Committee for Pfizer, Inc, and Janssen Alzheimer Immunotherapy, is a consultant for Elan Pharmaceuticals and GE Healthcare, and gave a Continuing Medical Education presentation for Novartis.
Identification
Copyright
© 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.
